SynthesisFrontiers in oncology2025
Global, regional, national burden of colorectal cancer from 1990 to 2021, with projections of incidence to 2050: a systematic analysis of the global burden of disease study 2021.
Synthesis in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Colorectal cancer (CRC) is a common malignant tumor of the digestive system, characterized by a high incidence and mortality rate. This study aimed to investigate the epidemiological characteristics of CRC between 1990 and 2021. Methods: Data on CRC were obtained from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021. We focused on the effects of age, sex, risk factors, and the socio-demographic index (SDI) on the burden of CRC. Estimated annual percentage changes (EAPCs) were calculated to evaluate changes in the age-standardized rate (ASR) of incidence, mortality and DALYs, as well as their trends in CRC burden. Frontier and health inequality analyses assessed health management potential and disease burden by country, while the Bayesian age-period-cohort (BAPC) model predicted CRC incidence patterns by age group through 2050. Findings: Global ASMR and ASDR declined, but ASIR rose overall (EAPC = 0.15), with significant gender disparities (male EAPC = 0.50 Interpretation: CRC burden varies by gender, age, and region. While some regions show declining mortality, overall burden remains substantial, especially in middle/low-middle SDI areas. Notably, even high-SDI countries exhibit significant gaps in CRC management. Targeted public health strategies-optimizing prevention, early detection, and resource allocation-are critical to address rising incidence and disparities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.