ArticleCureus2025
A Comparative Mixed Longitudinal Evaluation of Doxycycline Solution as an Aligner Rinse Compared With Conventional Mouthwashes on Microbial, Esthetic, and Inflammatory Outcomes During Orthodontic Tooth Movement.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionClear aligners are vulnerable to microbial colonization, discoloration, and inflammation-associated delays in orthodontic tooth movement. This study explores the use of sub-antimicrobial-dose doxycycline as a novel aligner disinfectant, owing to its combined antimicrobial, anti-inflammatory, and osteogenic effects.
objectiveThis study aims to compare the clinical, microbiological, and biological efficacy of 0.1% doxycycline solution versus 0.2% chlorhexidine gluconate in aligner therapy. MATERIALS AND
methodsA mixed longitudinal cohort design was employed, enrolling 60 patients undergoing aligner therapy. Participants received alternating aligners soaked in doxycycline (group A) and chlorhexidine (group B). Clinical indices, colony-forming units (CFUs), gingival crevicular fluid (GCF) alkaline phosphatase (ALP), and aligner transparency were evaluated at baseline, two weeks, one month, three months, and six months. Random allocation was performed using a computer-generated sequence. Outcome assessors were blinded. Microbial cultures, ALP assays, and spectrophotometric evaluations were conducted using standardized protocols.
resultsGroup A exhibited significantly lower plaque and gingival indices, reduced CFUs, enhanced aligner clarity, and elevated ALP levels compared to group B (p < 0.01). Pearson's correlation showed a strong inverse relationship between ALP and both CFUs and the gingival index.
conclusionsDoxycycline demonstrated superior microbial control, esthetic maintenance, and biological stimulation, supporting its potential role as a dual-action adjunct in aligner-based orthodontics. Further multicenter studies are recommended to validate these findings.
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