Evidence map›Paper›PMID 41122539›Full record

ReviewFrontiers in public health2025

Occupational hazards and bladder cancer-An umbrella review of the risk in workers exposed over the past 30 years.

Cristina Mandanach, Claudia Mariana Handra, Agripina Rascu, Sorina Hohor, Irina Luciana Gurzu, Marina Ruxandra Otelea, Alexandru Stefan Catalin Rascu

Abstract readReview
In one paragraph

Review in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cristina MandanachDoctoral School, University of Medicine and Pharmacy Carol Davila, Bucharest, Romania.
Claudia Mariana HandraClinical Department 5, University of Medicine and Pharmacy Carol Davila, Bucharest, Romania.
Agripina RascuClinical Department 5, University of Medicine and Pharmacy Carol Davila, Bucharest, Romania.
Sorina HohorDoctoral School, University of Medicine and Pharmacy Carol Davila, Bucharest, Romania.
Irina Luciana GurzuClinical Department 9, University of Medicine and Pharmacy Grigore T. Popa, Iaşi, Romania.
Marina Ruxandra OteleaClinical Department 5, University of Medicine and Pharmacy Carol Davila, Bucharest, Romania.
Alexandru Stefan Catalin RascuClinical Department 3, University of Medicine and Pharmacy Carol Davila, Bucharest, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Occupational exposure accounts for the second preventable risk factor for bladder cancer (BC), after smoking. Objective: This study aimed to extract evidence-based data from the systematic reviews that included studies primarily from the past 30 years, based on a clearly defined method of exposure assessment. Methods: A literature search in PubMed, Web of Science, ScienceDirect, and Embase was conducted using variations of the keywords "BC," "occupational exposure," and/or "occupation." The inclusion criteria for the umbrella review were the following: systematic reviews and meta-analyses focused on occupational exposure, with a clear definition of the exposure assessment, a risk estimate for BC, and a majority of data from 1993 to 2023. We did not include other forms of reviews or systematic reviews focused on the general population and environmental exposure. Data were synthesized based either on occupations or on occupational hazards. After the overlap checking, the remaining reviews were assessed for quality using AMSTAR 2 criteria and afterwards classified for high, moderate, or low evidence using the GRADE scale. Results: We found relevant associations with a high level of evidence for firefighters, hairdressers, painters, workers in the petroleum industry, and dry cleaners exposed to tetrachloroethylene. Concerning hazards, exposure to ortho-toluidine was also confirmed to be a risk by recent studies. Welders, veterans, and those exposed to hexavalent chromium at higher risk need more well-designed studies to be confirmed. Conclusion: Despite longstanding recognition of certain risks, occupational exposure remains insufficiently investigated. Recent data support the inclusion of occupations and hazards in the individual risk assessment for BC.

Indexed as

Occupational DiseasesOccupational ExposureUrinary Bladder NeoplasmsHumansMeta-Analysis as TopicRisk AssessmentRisk FactorsSystematic Reviews as Topicbladder cancercancer riskoccupational carcinogensoccupational exposureumbrella review

Identifiers

PMID41122539
PMCPMC12536731

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.