ArticleFrontiers in public health2025
The mediating effect of serum cortisol between stigma and post-stroke depression in stroke patients.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy and safety of electroacupuncture for post-stroke depression: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- Molecular biomarkers of cognitive impairment and neuropsychiatric symptoms after stroke in late-life-enriched cohorts: a scoping review.Journal of translational medicine · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aimed to explore the mediating effect of serum cortisol on the relationship between stigma and post-stroke depression (PSD) in patients with acute ischemic stroke. To enhance early screening for post-stroke depression and prevent its development. Methods: A total of 367 patients admitted to the Department of Neurology and Neurosurgery at Xuzhou Central Hospital between January and December 2024 were selected using a convenience sampling method. Participants completed a general information questionnaire and the 8-item Stigma Scale for Chronic Illness, and their serum cortisol levels were measured at 8:00 a.m. the day after admission. Spearman correlation was used to analyze the correlation between serum cortisol, stigma level and depression degree in patients with acute ischemic stroke. The mediating effect Model was tested by Model 4 model in the PROCESS plug-in. Results: Among the participants, 182 were in the PSD group and 185 in the non-PSD group, with significant differences in income, education, serum cortisol, and stigma levels between the groups ( Conclusion: These findings suggest that serum cortisol plays a partial mediating role between stigma and PSD in patients with acute ischemic stroke, highlighting a potential biological mechanism linking psychosocial stress to mental health outcomes in this population.
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