ArticleFrontiers in microbiology2025
Isolation and molecular characterization of subgroup J avian leukosis virus in native chicken breeds of China during 2022-2025.
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Untargeted metabolomics reveals remodeling of hepatic metabolic networks and potential tumor-associated metabolic signatures induced by ALV-J in Luhua chickens.Poultry science · 2026Article
- Biological characterization of an avian leukosis virus subgroup J isolate from yunnan indigenous black-bone chickens and generation of its full-length infectious clone.Archives of virology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Avian leukosis virus subgroup J (ALV-J) primarily infects poultry, especially chickens, where it induces immunosuppression and tumorigenesis. ALV-J has caused substantial economic losses worldwide and is prevalent among indigenous chicken breeds in China. In this study, we analyzed the genomic characteristics of ALV-J strains isolated from diseased liver tissue or anticoagulant blood samples collected from Lushi chickens, Central Plains cockfighting, and Hetian chickens between 2022 and 2025. The results showed that the nine isolates clustered within Clades 1.2 and 1.3, indicating that ALV-J is concurrently prevalent in multiple native chicken lineages. Compared with the ALV-J prototype strain HPRS-103, multiple specific functionally significant point mutations or deletion mutations occurred in the Gp85 protein and the 3' untranslated region (3' UTR) of all the isolates. These included the N123I mutation in the Gp85 protein, which stabilizes the Gp85 structure and expands the interaction interface, the D191N mutation suggesting the formation of a new N-glycosylation site, and the deletion mutations within the receptor-binding domain (RBD) that affect the efficiency of the binding between the virus and host cell receptors, as well as the reduced transmembrane (rTM) deletion mutation in the 3' UTR that influences the viral replication ability, suggesting that the isolates analyzed may exhibit enhanced replication ability and pathogenicity. In addition, there are certain differences in the number of α-helices in the Gp85 proteins of these ALV-J strains, and these differences may have an impact on the interaction between the virus and host. The results of our study are conducive to enriching the epidemiological data of ALV-J and revealing the genetic evolution direction of ALV-J strains, which will provide a scientific basis for the prevention and control of avian leukosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.