ArticleFrontiers in microbiology2025
Differences in gut microbiota among patients with anastomotic leak following colorectal cancer surgery.
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07416760 (Analysis of the Composition of the Intestinal Microbiota and Its Evolution in Patients Post-intestinal Anastomosis), which is not on this map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Analysis of the Composition of the Intestinal Microbiota and Its Evolution in Patients Post-intestinal Anastomosis
Who cites it
2 citing papers in PubMed.
- Perioperative microbiota at the colorectal anastomosis: local host-microbe interactions in healing and leak.Frontiers in surgery · 2026Review
- The gut microbiome in colorectal anastomotic leakage: from mechanisms to precision.Frontiers in medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Anastomotic leak (AL) continues to be one of the most severe complications following colorectal surgery, with its incidence showing little change over time. The causes of anastomotic leak are varied, and the precise underlying mechanisms remain elusive. However, there is a growing body of evidence indicating a significant association between the intestinal microbiota and the occurrence of anastomotic leak. Methods: This study aimed to investigate the preoperative gut microbiota in patients who developed anastomotic leak (AL) following colorectal surgery. We collected preoperative fecal samples from both patients who developed anastomotic leak and those who did not for clinical research. Utilizing 16S Ribosomal RNA (16S rRNA) sequencing, we examined differences in gut microbiota of preoperative patients with colorectal cancer to identify bacterial species that may either mitigate or exacerbate the risk of anastomotic leak. Additionally, we preoperatively fed mice with Results: We observed a significant increase in the diversity of intestinal microbiota in patients with anastomotic leak compared to those without. Specifically, the populations of Conclusion: This study indicates that the presence of
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.