Evidence map›Paper›PMID 41122461›Full record

ArticleFrontiers in microbiology2025

Time-course transcriptomics reveals the impact of

Sean Waugh, Mara C Goodyear, Alloysius Gomez, Akash Ranasinghe, Karen V Lithgow, Reza Falsafi, Robert E W Hancock, Amy H Lee, Caroline E Cameron

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Putative mechanisms of ocular inflammation in syphilis.Journal of ophthalmic inflammation and infection · 2026
    Review
  2. Human placental trophoblasts support sustainedbioRxiv : the preprint server for biology · 2026
    Article
  3. Frontiers in immunology · 2026
    Review
  4. Frontiers in cellular and infection microbiology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Sean WaughDepartment of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada.
Mara C GoodyearDepartment of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada.
Alloysius GomezDepartment of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada.
Akash RanasingheDepartment of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada.
Karen V LithgowDepartment of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada.
Reza FalsafiDepartment of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.
Robert E W HancockDepartment of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.
Amy H LeeDepartment of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada.
Caroline E CameronDepartment of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada.

Funding

University of Washington (UW) Sexually Transmitted Infections (STI) Cooperative Research Center (CRC) - Syphilis Vaccine to Protect against Local and Disseminated T. pallidum InfectionU19AI144133 · NIAID · UNIVERSITY OF WASHINGTON · PI WALD, ANNA · 2019 to 2023
$10.6M
Development of a Chimeric Syphilis Vaccine Candidate to Combat Local, Disseminated and Congenital Syphilis InfectionU01AI182035 · NIAID · UNIVERSITY OF VICTORIA · PI CAROLINE E CAMERON, Lorenzo Giacani · 2024 to 2026
$4.8M
Extracellular Matrix Adhesins of Treponema pallidumR37AI051334 · NIAID · UNIVERSITY OF VICTORIA · PI CAROLINE E CAMERON · 2019 to 2026
$2.3M
INFLUENZA B: GENE SEQUENCESR01AI018203 · NIAID · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI AIR, GILLIAN M. · 1985 to 2007
$1.5M
NIAID NIH HHS R01 AI018203NIAID NIH HHS R37 AI051334NIAID NIH HHS U01 AI182035NIAID NIH HHS U19 AI144133
6 · The paper itself

Abstract

Syphilis, caused by

Indexed as

endothelial cellpathogenesissyphilistranscriptomicsTreponema pallidumvaccine

Identifiers

PMID41122461
PMCPMC12535989

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.