Evidence map›Paper›PMID 41122448›Full record

ArticleMedComm2025

Retinal Pigment Epithelium-Targeting Gene Therapy Corrects Ocular Symptoms in Mouse and Rat Models of Oculocutaneous Albinism Type I.

Li Song, Chengda Ren, Min Luo, Jing Su, Xiu Jin, Jiamei Fu, Qiuxia Xu, Xiaoyi Wu, Fanfei Liu, Qin Ye and 9 more

Abstract read
In one paragraph

Article in MedComm, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Li SongState Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University and Collaborative Innovation Center Chengdu China.
Chengda RenDepartment of Ophthalmology West China Hospital Sichuan University Chengdu China.
Min LuoState Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University and Collaborative Innovation Center Chengdu China.
Jing SuState Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University and Collaborative Innovation Center Chengdu China.
Xiu JinState Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University and Collaborative Innovation Center Chengdu China.
Jiamei FuState Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University and Collaborative Innovation Center Chengdu China.
Qiuxia XuState Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University and Collaborative Innovation Center Chengdu China.
Xiaoyi WuState Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University and Collaborative Innovation Center Chengdu China.
Fanfei LiuDepartment of Ophthalmology West China Hospital Sichuan University Chengdu China.
Qin YeState Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University and Collaborative Innovation Center Chengdu China.
Ming HuDepartment of Ophthalmology West China Hospital Sichuan University Chengdu China.
Man LiuState Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University and Collaborative Innovation Center Chengdu China.
Qiqi LiState Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University and Collaborative Innovation Center Chengdu China.
Yifang AnState Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University and Collaborative Innovation Center Chengdu China.
Manjun LiDepartment of Ophthalmology West China Hospital Sichuan University Chengdu China.
Qingnan WangChengdu Genevector Therapeutics, Inc. Chengdu China.
Kaiqin SheDepartment of Ophthalmology West China Hospital Sichuan University Chengdu China.
Fang LuDepartment of Ophthalmology West China Hospital Sichuan University Chengdu China.
Yang YangState Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University and Collaborative Innovation Center Chengdu China.ORCID https://orcid.org/0000-0002-8190-1825

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oculocutaneous albinism (OCA) represents a genetically heterogeneous autosomal recessive condition marked by reduced melanin production in cutaneous and ocular tissues. This disorder primarily arises from mutations in the

Indexed as

gene therapyOCA1RPE‐specific promotersubretinalsuprachoroidal

Identifiers

PMID41122448
PMCPMC12536886

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.