Evidence map›Paper›PMID 41122398›Full record

ArticleRSC advances2025

Uric acid electrochemical biosensor based on a laser-induced graphene electrode modified with a Honey-mediated nanocomposite of reduced graphene oxide and bimetallic silver-cobalt.

Isa Anshori, Arini Rahma Adzkia, Uperianti, Suksmandhira Harimurti, Nurrahmi Handayani, Veinardi Suendo, Muhammad Ali Zulfikar, Annop Klamchuen, Chih-Yu Chang, Murni Handayani

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Isa AnshoriLab on Chip Laboratory, Biomedical Engineering Department, School of Electrical Engineering and Informatics, Institut Teknologi Bandung Bandung 40132 Indonesia isaa@staff.stei.itb.ac.id.ORCID https://orcid.org/0000-0001-5134-7264
Arini Rahma AdzkiaLab on Chip Laboratory, Biomedical Engineering Department, School of Electrical Engineering and Informatics, Institut Teknologi Bandung Bandung 40132 Indonesia isaa@staff.stei.itb.ac.id.
UperiantiLab on Chip Laboratory, Biomedical Engineering Department, School of Electrical Engineering and Informatics, Institut Teknologi Bandung Bandung 40132 Indonesia isaa@staff.stei.itb.ac.id.
Suksmandhira HarimurtiFlexens Laboratory, Department of Electrical Engineering, School of Electrical Engineering, Telkom University Main Campus Bandung 40257 Indonesia sukman@telkomuniversity.ac.id.ORCID https://orcid.org/0000-0002-8596-5578
Nurrahmi HandayaniResearch Center for Nanosciences and Nanotechnology, Institut Teknologi Bandung Bandung 40132 Indonesia.
Veinardi SuendoResearch Center for Nanosciences and Nanotechnology, Institut Teknologi Bandung Bandung 40132 Indonesia.ORCID https://orcid.org/0000-0002-3402-433X
Muhammad Ali ZulfikarDivision of Analytical Chemistry, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung Bandung 40132 Indonesia.
Annop KlamchuenNational Nanotechnology Center (NANOTEC), NSTDA 111 Thailand Science Park, Paholyothin Rd. Klong Luang Pathum Thani 12120 Thailand.ORCID https://orcid.org/0000-0002-0477-4893
Chih-Yu ChangDepartment of Materials Science and Engineering, National Taiwan University of Science and Technology No. 43 Keelung Road, Sec. 4, Da'an District Taipei 10607 Taiwan (R.O.C.).
Murni HandayaniResearch Center for Nanotechnology Systems - National Research and Innovation Agency (BRIN) Puspitek Area Tangerang Selatan 15314 Indonesia murn003@brin.go.id.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Abnormal uric acid (UA) levels are commonly linked to several metabolomic or internal organ problems. Electrochemical-based tests have been used as alternative early screening methods to determine the levels of biomarkers, including UA. Electrochemical biosensors based on laser-induced graphene (LIG) electrodes could offer a promising alternative to realize a low-cost biosensor for biomarker detection. In this study, an LIG electrode was modified with a nanocomposite composed of reduced graphene oxide and silver-cobalt bimetal (rGO/AgCo), resulting in its enhanced sensitivity and selectivity for the detection of UA. Furthermore, to promote eco-friendliness, honey was utilized as the mediator to reduce and stabilize the nanoparticles during the creation of the nanocomposite. Differential pulse voltammetry (DPV) test results revealed that the nanocomposite-modified electrode exhibited excellent selectivity and electrochemical characteristics for the detection of UA, with a linear range of 0.1-2000 μM, limit of detection (LOD) of 3.75 μM, limit of quantification (LOQ) of 11.36 μM, and sensitivity of 1.76 μA μM

Identifiers

PMID41122398
PMCPMC12536868

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.