ArticleFrontiers in neuroscience2025
Correlation of N-acetylaspartyl glutamate level in the medial prefrontal cortex with FTND and daily smoking amounts in adult cigarette smokers.
Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The neurotransmitter excitation/inhibition (E/I) balance is critical for maintaining normal brain function, and the contribution of nicotine signaling to homeostasis regulation and maintenance of E/I ratios is only beginning to be understood. Advanced Method: In 2022, 45 males aged 40-60 years old were recruited. All subjects underwent routine magnetic resonance imaging (MRI) and the Results: All measured metabolite levels in the brain mPFC region of smokers showed no significant difference to those of the control subjects. While the NAAG levels with reference to total creatine or water signals in smokers was significantly correlated with daily smoking volume, and the level of NAAG/Cr was potentially correlated with the FTND score. Conclusions: In this study, we observed that the level of medial prefrontal NAAG in smokers was associated with daily smoking volume. This suggests that the metabolism of NAAG in the brain is related to nicotine, and the balance of glutaminergic system in the brain of smokers may be disrupted.
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