ArticleAdvances in neurodevelopmental disorders2024
Urinary Histamine Not Associated with Severity of Symptoms of ADHD and Emotional Dysregulation: A Cross-sectional Secondary Data Analysis from the Micronutrients for ADHD in Youth (MADDY) Study.
Article in Advances in neurodevelopmental disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: Histamine, a critical regulator of attention and inflammatory processes, may play a role in symptoms of attention-deficit/hyperactivity disorder (ADHD). Methods: Data were from the baseline visit of a multi-site randomized controlled trial in children aged 6-12 with symptoms of ADHD and emotional dysregulation, the Micronutrients for ADHD in Youth (MADDY) study. Parent-reported intake of high-histamine foods was assessed with the VioScreen questionnaire; symptoms of ADHD with the Child & Adolescent Symptom Inventory, version-5 (CASI-5) Inattention and Hyperactivity/Impulsivity subscales, and emotional dysregulation with the Strengths & Difficulties Questionnaire-Dysregulation Profile. Urinary histamine was analyzed with liquid chromatography-mass spectrometry, with reference ranges for children < 10 and 10-12 years old. Results: Thirty percent of children < 10 years old and 81% of children 10-12 (57% overall) had urinary histamine levels above the upper limit of the reference range. Urinary histamine was not associated with inattention, hyperactivity/impulsivity, or emotional dysregulation, nor intake of high-histamine foods, in the entire sample ( Conclusions: In this secondary data analysis, urinary histamine levels were not associated with severity of hyperactivity/impulsivity or emotional dysregulation, or intake of high-histamine foods. Children with high urinary histamine had increased inattention compared to those with normal histamine levels. Limitations include the homogeneity of the sample and the lack of a comparison group without ADHD.
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