ArticleActa naturae
RNA Interference of the Genes Associated with the Invasion of Brain Tumor Cells.
Article in Acta naturae. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
High-grade gliomas are among the most aggressive malignant pathologies of the brain. The high invasive potential of tumor cells causes relapses of the disease even after radical resection of the tumor. The signatures of the genes associated with the invasion of glioma cells have now been identified. The expression products of these genes are involved in various signaling pathways, such as cellular protein catabolism, the p53 signaling pathway, transcription dysregulation, and the JAK-STAT signaling pathway. Therefore, they can indirectly modulate the invasive potential of tumor cells. Using RNA interference technology, it is possible to change the expression level of the detected genes and reduce the invasive and proliferative potentials of cancer cells. This review focuses on the use of this technology to influence various links in signaling pathways and, accordingly, the cellular processes associated with the invasion of glioblastoma cells. Furthermore, the review discusses the problems associated with delivering interfering RNAs into cells and ways to solve them.
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