Evidence map›Paper›PMID 41122295›Full record

ArticleFrontiers in genome editing2025

From GWAS signal to function: targeted CRISPR activation enables functional characterization of non-coding SNPs in chickens.

Jaewon Kim, Jeong Hoon Han, Minjun Kim, Grace Schmidt, Eunjin Cho, Jun Heon Lee, Tae Hyun Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genome editing, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jaewon KimDepartment of Animal Science and Biotechnology, Chungnam National University, Daejeon, Republic of Korea.
Jeong Hoon HanDepartment of Animal Science, The Pennsylvania State University, University Park, PA, United States.
Minjun KimDepartment of Animal Science and Biotechnology, Chungnam National University, Daejeon, Republic of Korea.
Grace SchmidtDepartment of Animal Science, The Pennsylvania State University, University Park, PA, United States.
Eunjin ChoDepartment of Bio-AI Convergence, Chungnam National University, Daejeon, Republic of Korea.
Jun Heon LeeDepartment of Animal Science and Biotechnology, Chungnam National University, Daejeon, Republic of Korea.
Tae Hyun KimDepartment of Animal Science, The Pennsylvania State University, University Park, PA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genome-wide association studies (GWAS) have identified numerous single nucleotide polymorphisms (SNPs) associated with complex traits in poultry. However, most GWAS-identified variants reside in non-coding regions, making their functional relevance to their phenotypes unclear. Emerging evidence suggests that many of these markers overlap

Indexed as

chickenscis-regulatory elementCRISPRaCRISPR activationFAANGGWASnon-coding SNP

Identifiers

PMID41122295
PMCPMC12536144

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.