ArticleMediterranean journal of rheumatology2025
The Effect of Vitamin D Supplementation on Clinical and Laboratory Biomarkers in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.
Article in Mediterranean journal of rheumatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of vitamin D3 supplementation on systemic inflammation and disease-specific markers in patients with autoimmune diseases: a comprehensive meta-analysis of randomized controlled trials.Inflammopharmacology · 2026Pooled it
- Effects of Vitamin D on Epigenetics, Seasonality, and Management of Rheumatoid Arthritis.Nutrients · 2026Review
- Vitamin D as an Immuno-Endocrine Modulator: Discovering Its Role in Autoimmune Disorders and Host Defense Mechanisms.Journal of clinical medicine · 2026Review
- Correlations Between Serum Vitamin D, Synovial Succinic Acid Levels and Disease Activity in Patients with Rheumatoid Arthritis.Journal of inflammation research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim: Rheumatoid arthritis (RA) is recognised as an inflammatory condition. Evidence indicates that vitamin D modulates inflammation by influencing diverse immune cells. The purpose of this systematic review and meta-analysis was to assess the effectiveness of vitamin D as a supplement for RA in comparison to a control group. Methods: We searched PubMed, Embase, Scopus, and Web of Science databases through March 2025 using targeted search terms. Our inclusion criteria encompassed clinical studies that enrolled RA patients and compared vitamin D supplementation against either placebo or standard care protocols. The results from the chosen studies were reported as Standardised mean differences (SMD) using random effect model with a 95% confidence interval. Results: Vitamin D supplementation resulted in a significant improvement in the VAS [SMD = -1.54, 95% CI (-2.53, -0.55), P = 0.002], serum vitamin D level [SMD = 1.52, 95% CI (0.86, 2.17), P = 0.001] and CRP [SMD = -0.88, 95% CI (-1.31, -0.44), P =0.001] but not in other outcomes. There was considerable heterogeneity among the studies for VAS (I Conclusion: The intervention groups receiving vitamin D supplementation showed statistically significant improvements in serum vitamin D levels, visual analog scale VAS scores, and CRP levels compared to control groups among RA patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.