Evidence map›Paper›PMID 41122129›Full record

ArticleFrontiers in ophthalmology2025

Choroidal measurements in patients affected by PXE-related retinopathy.

Dario Pasquale Mucciolo, Vittoria Murro, Dario Giorgio, Federica Boraldi, Laura Pavese, Daniela Quaglino, Andrea Sodi, Marco Branchetti, Liliana Pollazzi, Gianni Virgili and 1 more

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Article in Frontiers in ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Dario Pasquale MuccioloDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Vittoria MurroDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Dario GiorgioSOC Oculistica Firenze, Azienda USL Toscana Centro, Firenze, Italy.
Federica BoraldiDepartment of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Laura PaveseStruttura Complessa di Malattie Oftalmologiche, Azienda Ospedaliero Universitaria di Modena, Modena, Italy.
Daniela QuaglinoDepartment of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Andrea SodiDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Marco BranchettiDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Liliana PollazziDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Gianni VirgiliDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Fabrizio GiansantiDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To investigate the choroid in patients affected by pseudoxanthoma elasticum (PXE)-related retinopathy using the choroidal vascularity index (CVI). Methods: PXE patients and controls were recruited at the Eye Clinic in Florence. High-resolution imaging optical coherence tomography (OCT) scans (12 × 9 mm) of 32 PXE patients and 20 age-matched controls were examined. Images were binarized using the ImageJ software, and subfoveal choroidal thickness (SFCT), luminal area (LA), stromal area (SA), total choroidal area (TCA), and CVI were measured. Results: Sixty-four eyes of 32 PXE patients (mean age 45.65 ± 16.12; range 14-69) and 40 eyes of 20 controls (mean age 47.3 ± 13.7; range 18-71) were included in the study. SFCT was significantly lower in PXE patients compared to controls. The LA, SA, and TCA of the PXE patients were significantly reduced in comparison with those obtained for controls (p = 0.012, p < 0.001, and p = 0.001, respectively). On the contrary, the CVI did not significantly differ between patients and controls (p = 0.744). In young subjects, differences regarding SFCT, LA, SA, TCA, and CVI were not detected between PXE patients and healthy controls (p = 0.170, p = 0.990, p = 0.264, p = 0.351, and p = 0.487, respectively). Conclusion: In PXE-related retinopathy, choroidal impairment appears progressive with age, and there is a simultaneous, proportional impairment of both the stromal and vascular components of the choroid.

Indexed as

ABCC6choroidchoroidal vascularity indexOCTpseudoxanthoma elasticumPXE

Identifiers

PMID41122129
PMCPMC12535881

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