Evidence map›Paper›PMID 41122124›Full record

ReviewCurrent medical mycology2025

Is there a difference in the expression levels of genes responsible for fluconazole resistance in

Akbar Hoseinnejad, Mehrnoush Maheronnaghsh, Mojtaba Taghizadeh Armaki, Jalal Jafarzadeh, Mahnaz Fatahinia

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PubMed Full text at PMC Publisher
In one paragraph

Review in Current medical mycology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Akbar HoseinnejadStudent Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Mehrnoush MaheronnaghshDepartment of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Mojtaba Taghizadeh ArmakiInfectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Jalal JafarzadehStudent Research Committee, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Mahnaz FatahiniaDepartment of Medical Mycology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Purpose: Fluconazole is one of the primary antifungal agents in the treatment of candidiasis. However, long-term treatment and indiscriminate use of drugs from the azole family have created resistant isolates. Materials and Methods: Databases, such as PubMed, Scopus, and Web of Science were used to collect studies evaluating the expression levels of key Results: This systematic review identified the genes encoding the ATP-binding cassette membrane pump (CDR1, CDR2) and the genes encoding the major facilitator superfamily pumps (MDR1), as well as the Conclusion: Comprehensive information about the activity of the genes and more studies on the genes involved in resistance, could provide valuable insights for further studies, prevent the occurrence of resistance to fluconazole and other azoles, and provide suitable treatments. The disease, as well as the dosage and duration of the antifungal therapy, may play an important role in determining the type of resistance mechanism of

Indexed as

Candida albicansFluconazole resistanceGene expressionSystematic reviewUnderlying diseases

Identifiers

PMID41122124
PMCPMC12536819

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.