Association between systemic immune-inflammation index, systemic inflammation response index, and adverse outcomes in aneurysmal subarachnoid hemorrhage: a meta-analysis.

Purpose: This systematic review seeks to explore the link of the systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI), to adverse outcomes (AOs) in aneurysmal subarachnoid hemorrhage (aSAH). The findings may provide scientific evidence to enable the timely identification of patients at high risk and guide the formulation of personalized treatment strategies. Patients and methods: PubMed, Cochrane, Embase, and Web of Science databases were comprehensively retrieved from inception to August 10, 2024. The Newcastle-Ottawa Scale (NOS) was leveraged for appraise the quality of the encompassed studies. Statistical analyses were undertaken via Stata 17.0, and a bivariate mixed-effects model was applied for diagnostic value evaluation. Results: Sixteen studies involving 4,510 aSAH individuals were encompassed. The meta-analysis demonstrated SII as a predictor of poor 90-day outcomes [Odds Ratio (OR) = 1.94, 95% Confidence Interval (CI): 1.35-2.78, Conclusion: Both SII and SIRI serve as predictive biomarkers for unfavorable 90-day outcomes in the aSAH population, with SII also demonstrating predictive value for DCI. While both indices exhibit moderate accuracy, further research is necessitated to validate their clinical utility. Clinical trial registration: https://www.crd.york.ac.uk/PROSPERO/, Registration No: CRD42024585116.