ReviewAnnals of medicine2025
Research progress on scar-free healing.
Review in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Ultradeformable Vesicles for Wound Healing: Ethosomes, Transferosomes, and Transethosomes in Topical Drug Delivery.Pharmaceutics · 2026Review
- Fibroblast Lineage Switching as the Developmental Origin of Scarring and Target for Regenerative Healing.Biology · 2026Review
- Fisetin promotes skin wound healing and inhibits pathological scar formation through modulation of the PI3K/Akt/TGF-β1 signaling axis.Frontiers in pharmacology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPathological scars resulting from wound healing can cause functional impairment, cosmetic disfigurement, and psychological distress, highlighting the urgent need for regenerative solutions. Scar-free healing observed in embryonic development and some adult mammalian models have achieved complete tissue repair without fibrosis.
methodsThis article reviews literature on wound healing and scarless healing published over the past 25 years. The databases searched were PubMed/MEDLINE, Embase, Web of Science, CNKI, Wanfang, and ChiCTR (used to supplement research from Chinese scholars). Search terms included 'wound healing,' 'scarless healing,' 'scar-free healing,' 'embryo,' 'immunotherapy' and 'tissue engineering therapy,' among others. Additionally, the reference lists of key articles were examined to identify further relevant studies. DISCUSSION: In this article, we reviewed the influencing factors of scarless healing, covering both macroscopic and microscopic factors-including fibroblasts, collagen, matrix metalloproteinases, neurological influences, and cytokines-which are key therapeutic targets in clinical practice. It details four critical signalling pathways: (1) the SDF-1/CXCR4 axis, (2) the Wnt signalling pathway, (3) the [Ca
conclusionThe formation of scars is influenced by multiple internal and external factors. To achieve scar-free healing, a combination of multiple effective treatment methods is required, such as targeting related signalling pathways or genes. Furthermore, immunotherapy-related approaches hold great potential and require further research to clarify the relevant reaction processes in order to develop new and effective treatment methods.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.