Evidence map›Paper›PMID 41122018›Full record

ArticleInternational journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group2025

Histotripsy of the hepatic capsule and the gastric wall: acute treatment effects in a swine model.

Meridith A Kisting, Adrienne L Kisting, Shreya L Kurichety, Allison B Couillard, Anna M Sorensen, Emily A Knott, Jim K White, Charles W Bradley, Katrina L Falk, J Louis Hinshaw and 7 more

Abstract read
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In one paragraph

Article in International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Meridith A KistingDepartment of Radiology, University of Wisconsin, Madison, WI, USA.
Adrienne L KistingDepartment of Radiology, University of Wisconsin, Madison, WI, USA.
Shreya L KurichetyDepartment of Radiology, University of Wisconsin, Madison, WI, USA.
Allison B CouillardDepartment of Radiology, University of Wisconsin, Madison, WI, USA.
Anna M SorensenDepartment of Radiology, University of Wisconsin, Madison, WI, USA.
Emily A KnottCleveland Clinic Lerner College of Medicine, Cleveland Clinic.
Jim K WhiteDepartment of Radiology, University of Wisconsin, Madison, WI, USA.
Charles W BradleyDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania.
Katrina L FalkDepartment of Radiology, University of Wisconsin, Madison, WI, USA.ORCID 0000-0001-7646-2541
J Louis HinshawDepartment of Radiology, University of Wisconsin, Madison, WI, USA.
Meghan G LubnerDepartment of Radiology, University of Wisconsin, Madison, WI, USA.
John F SwietlikDepartment of Radiology, University of Wisconsin, Madison, WI, USA.ORCID 0000-0002-7180-794X
Martin G WagnerMedical Physics, University of Wisconsin, Madison, WI, USA.
Paul F LaesekeDepartment of Radiology, University of Wisconsin, Madison, WI, USA.
Eli VlaisavljevichDepartment of Biomedical Engineering, Virginia Technologic University.
Fred T LeeDepartment of Radiology, University of Wisconsin, Madison, WI, USA.
Timothy J ZiemlewiczDepartment of Radiology, University of Wisconsin, Madison, WI, USA.ORCID 0000-0002-7033-1062

Funding

Integrated Training For Physician-ScientistsT32GM140935 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Anna Huttenlocher, Jeniel E Nett · 2021 to 2026
$6.5M
Advanced multimodal image-guided histotripsy for precise, safe and effective histotripsy of liver tumorsR01EB031007 · NIBIB · UNIVERSITY OF WISCONSIN-MADISON · PI Paul F Laeseke, Martin Gerd Wagner · 2022 to 2026
$2.5M
Developing Methods for Precise, Safe and Target-location Specific Histotripsy of Liver TumorsR01CA262474 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI ZIEMLEWICZ, TIMOTHY J · 2021 to 2025
$2.4M
Developing an Accurate and Robust Targeting Technique to Enable Transcostal Histotripsy Treatment of Liver TumorsF30CA284541 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Katrina Lauren Falk · 2024 to 2026
$135k
NCI NIH HHS F30 CA284541NCI NIH HHS R01 CA262474NIBIB NIH HHS R01 EB031007NIGMS NIH HHS T32 GM140935NIH HHS 1F30CA28454101A1
6 · The paper itself

Abstract

purposeTo evaluate the safety of histotripsy at the hepatic capsule when the treatment zone extends into the gastric wall in a live porcine model.

methodsSpherical 2.5 cm histotripsy treatments (

resultsHistotripsy of the liver and adjacent stomach was technically successful in all cases (12/12). There was no statistically significant difference in treatment zone size when the stomach was inflated or collapsed. Gross pathologic evidence of gastric injury was noted in 12/12 subjects without evidence of perforation or gastric leak. CT evidence of gastric injury was observed in 10/12 treatments without evidence of gastric perforation or leakage noted (12/12). Stomach histopathology confirmed injuries as partial (non-transmural) in 11/12 cases and complete (transmural) in 1/12 cases (collapsed stomach).

conclusionsHistotripsy performed at the hepatic capsule with treatment margins extending into the stomach generally results in minor, partial thickness gastric injuries, which are not worsened by the presence of gas. Full thickness injuries are however possible and caution should be exercised to minimize the amount of stomach wall overlap.

Indexed as

LiverStomachAnimalsFemaleSwinefocused ultrasoundgastrichepatocellular carcinomaHistotripsyliver metastasis

Identifiers

PMID41122018
PMCPMC12967312

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.