Evidence map›Paper›PMID 41121990›Full record

ArticleJournal of cellular and molecular medicine2025

Detection of Gliadin-Activated CD4

Laura Pisapia, Marcella D'Ambrosio, Ilaria Mottola, Stefania Picascia, Domenico De Girolamo, Fabiana Castiglione, Nadia Tinto, Antonio Rispo, Carmen Gianfrani, Giovanna Del Pozzo

Abstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Detection of Gliadin-Activated CD4Journal of cellular and molecular medicine · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Laura PisapiaInstitute of Genetics and Biophysics, CNR, Naples, Italy.
Marcella D'AmbrosioInstitute of Genetics and Biophysics, CNR, Naples, Italy.
Ilaria MottolaInstitute of Biochemistry and Cell Biology, CNR, Naples, Italy.
Stefania PicasciaInstitute of Endotypes in Oncology, Metabolism and Immunology "G. Salvatore", CNR, Naples, Italy.
Domenico De GirolamoDepartment of Molecular Medicine and Medical Biotechnology, CEINGE Advanced Biotechnologies "Franco Salvatore", Naples, Italy.
Fabiana CastiglioneGastroenterology, Department of Clinical Medicine and Surgery, University Federico II, Naples, Italy.
Nadia TintoDepartment of Molecular Medicine and Medical Biotechnology, CEINGE Advanced Biotechnologies "Franco Salvatore", Naples, Italy.
Antonio RispoGastroenterology, Department of Clinical Medicine and Surgery, University Federico II, Naples, Italy.
Carmen GianfraniInstitute of Biochemistry and Cell Biology, CNR, Naples, Italy.
Giovanna Del PozzoInstitute of Genetics and Biophysics, CNR, Naples, Italy.ORCID 0000-0001-8937-9018

Funding

Consiglio Nazionale delle Ricerche FOE 2021 DBA.AD005.225Consiglio Nazionale delle Ricerche FOE 2022 DSB.AD006.371
6 · The paper itself

Abstract

The diagnosis of celiac disease (CD) relies on the presence of serum antibodies against type 2-tissue transglutaminase (tTG2) and endomysium, which in adult patients must be confirmed by assessing small intestinal mucosa damage through esophagogastroduodenoscopy. We aim to establish a non-invasive method focused on detecting activated CD4

Indexed as

CD4-Positive T-LymphocytesCeliac DiseaseGliadinLymphocyte ActivationAdultBiomarkersCase-Control StudiesDiet, Gluten-FreeFemaleFlow CytometryGTP-Binding ProteinsHumansMaleMiddle AgedProtein Glutamine gamma Glutamyltransferase 2Receptors, OX40BiomarkersGliadinGTP-Binding ProteinsProtein Glutamine gamma Glutamyltransferase 2Receptors, OX40TransglutaminasesautoimmunityCD4 lymphocyte activation markersdiagnosisgliadin

Identifiers

PMID41121990
PMCPMC12541239

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.