Evidence map›Paper›PMID 41121750›Full record

ReviewMedicinal research reviews2026

Light-Based Molecular Tools to Precisely Monitor and Operate β-Adrenoceptors.

Ignazzitto Maria Tindara, Gómez-Santacana Xavier, Llebaria Amadeu, Rovira Xavier

Abstract readReview
In one paragraph

Review in Medicinal research reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ignazzitto Maria TindaraLaboratory of Medicinal Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, Catalonia, Spain.
Gómez-Santacana XavierLaboratory of Medicinal Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, Catalonia, Spain.
Llebaria AmadeuLaboratory of Medicinal Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, Catalonia, Spain.ORCID 0000-0002-8200-4827
Rovira XavierLaboratory of Medicinal Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, Catalonia, Spain.ORCID 0000-0002-9764-9927

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

β-Adrenoceptors are important G protein-coupled receptors involved in cardiovascular, metabolic, and neurological regulation. To study their function with high precision, light-based molecular tools have been developed offering precise spatiotemporal control. Fluorescence and bioluminescence techniques allow real-time monitoring of receptor activation and organization, while photopharmacology and optogenetics enable precise external modulation of their activity. A particularly valuable approach involves photoswitchable ligands, which can be switched on and off by specific wavelengths and provide reversible control over receptor activity. In general, the combination of optical biosensing and photopharmacology enhances our ability to analyze GPCR signaling dynamics and function with minimal perturbation. In particular, these approaches open new avenues for targeted research and therapeutic interventions, offering a powerful framework for understanding β-adrenoceptors-related diseases.

Indexed as

LightReceptors, Adrenergic, betaAnimalsBiosensing TechniquesHumansLigandsOptogeneticsSignal TransductionLigandsReceptors, Adrenergic, betaazobenzenebioluminescencefluorescencephotopharmacologyβ‐adrenoceptors

Identifiers

PMID41121750
PMCPMC12865269

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.