Evidence map›Paper›PMID 41121580›Full record

ArticleProteomics2025

JUMPshiny: A User-Friendly Platform for Comprehensive Analysis and Visualization of Quantitative Proteomics Data.

Aijun Zhang, Yingxue Fu, Zuo-Fei Yuan, Long Wu, Dehui Kong, Ling Li, Zhiping Wu, Pjotr Prins, Junmin Peng, Xusheng Wang

Abstract read
In one paragraph

Article in Proteomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Aijun ZhangDepartment of Neurology, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Yingxue FuCenter For Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID 0000-0003-3052-4131
Zuo-Fei YuanCenter For Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Long WuCenter For Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Dehui KongDepartment of Neurology, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Ling LiDepartment of Neurology, University of Tennessee Health Science Center, Memphis, Tennessee, USA.ORCID 0000-0001-6295-2128
Zhiping WuDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Pjotr PrinsDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Junmin PengDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID 0000-0003-0472-7648
Xusheng WangDepartment of Neurology, University of Tennessee Health Science Center, Memphis, Tennessee, USA.ORCID 0000-0002-1759-9588

Funding

Project 4 (Genetic modifiers for APOE-associated Alzheimer's disease pathogenesis)U19AG069701 · NIA · MAYO CLINIC JACKSONVILLE · PI Yingxue Ren · 2021 to 2026
$42.0M
Systems Approaches to Novel Molecular Mechanism in Alzheimer's DiseaseRF1AG064909 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI PENG, JUNMIN, YU, GANG · 2019 to 2024
$6.4M
Identification of gene variants mediating the behavioral and physiological response to THCR01DA056523 · NIDA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI Bob Mack Moore, Megan Kathleen Mulligan · 2023 to 2026
$3.0M
Validation of a novel tau clearance mechanism.RF1AG072703 · NIA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI BHASKAR, KIRAN, LI, WEI · 2022 to 2022
$2.2M
NIDA NIH HHS R01 DA056523NIH/NIA R01 R01DA056523NIH/NIA R01 RF1AG064909NIH/NIA R01 RF1AG072703NIH/NIA R01 U19AG069701
6 · The paper itself

Abstract

Mass spectrometry-based quantitative proteomics has revolutionized our understanding of biological processes and unveiled the molecular mechanisms underlying various diseases. The analysis and visualization of quantitative proteomics data remain complex and require user-friendly tools with robust analytical capacities. In this study, we introduce JUMPshiny, a novel, interactive, and comprehensive web-service, that is built on R-Shiny and designed for processing and presenting quantitative proteomics data. JUMPshiny includes a wide range of visualizations and offers a streamlined workflow, including experimental design, data exploration, batch normalization, differential analysis, and enrichment analysis. Through examples, we demonstrate automated quality control, interactive data visualization, and customizable statistical analyses. Built on the R-Shiny framework, JUMPshiny integrates established libraries and packages to ensure computational robustness and reproducibility. Overall, JUMPshiny represents a powerful platform for proteomics data analysis for the research community. JUMPshiny is available at https://jumpshiny.genenetwork.org. The source code is available under MIT license at: https://github.com/Wanglab-UTHSC/JUMP_shiny.

Indexed as

Computational BiologyProteomicsSoftwareHumansInternetMass SpectrometryUser-Computer Interfacebioinformatics toolsdata analysisdata visualizationJUMPshinymass spectrometryquantitative proteomicsR packagessoftwareweb application

Identifiers

PMID41121580
PMCPMC13182756

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.