Evidence map›Paper›PMID 41121434›Full record

ArticleJournal of medical case reports2025

Bariatric surgery and semaglutide in a youth with juvenile Huntington disease and severe obesity: a case report.

Alaina P Vidmar, Matthew J Martin, Stuart Abel, Aimee G Kim, Cynthia E Muñoz, Madeleine Weitzner, Sabrina F Derrington, Kamran Samakar

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alaina P VidmarDepartment of Pediatrics, Center for Endocrinology, Diabetes and Metabolism, Children's Hospital Los Angeles and Keck School of Medicine of University of Southern California, 4650 Sunset Blvd. Mailstop 61, Los Angeles, CA, USA. avidmar@chla.usc.edu.ORCID http://orcid.org/0000-0003-3790-6255
Matthew J MartinDivision of Upper Gastrointestinal and General Surgery, Department of Surgery, Keck Medical Center of University of Southern California, Los Angeles, CA, USA.
Stuart AbelDivision of Upper Gastrointestinal and General Surgery, Department of Surgery, Keck Medical Center of University of Southern California, Los Angeles, CA, USA.
Aimee G KimDepartment of Surgery, Center for Endocrinology, Diabetes and Metabolism, Children's Hospital Los Angeles and Keck School of Medicine of USC, Los Angeles, CA, USA.
Cynthia E MuñozDepartment of Pediatrics, Center for Endocrinology, Diabetes and Metabolism, Children's Hospital Los Angeles and Keck School of Medicine of University of Southern California, 4650 Sunset Blvd. Mailstop 61, Los Angeles, CA, USA.
Madeleine WeitznerDepartment of Pediatrics, Center for Endocrinology, Diabetes and Metabolism, Children's Hospital Los Angeles and Keck School of Medicine of University of Southern California, 4650 Sunset Blvd. Mailstop 61, Los Angeles, CA, USA.
Sabrina F DerringtonDepartment of Pediatrics, Center for Endocrinology, Diabetes and Metabolism, Children's Hospital Los Angeles and Keck School of Medicine of University of Southern California, 4650 Sunset Blvd. Mailstop 61, Los Angeles, CA, USA.
Kamran SamakarDivision of Upper Gastrointestinal and General Surgery, Department of Surgery, Keck Medical Center of University of Southern California, Los Angeles, CA, USA.

Funding

American Diabetes Association Research Foundation 11-22-ICTSN-32.Division of Diabetes, Endocrinology, and Metabolic Diseases K23DK134801
6 · The paper itself

Abstract

backgroundManaging severe obesity in youth with chronic, progressive conditions, such as juvenile Huntington disease, presents unique challenges. Juvenile Huntington disease, is characterized by rapid neurodegeneration, with most patients experiencing a significant decline in motor and cognitive functions within 10-20 years of symptom onset, leading to reduced life expectancy. Obesity further complicates these conditions, reducing quality of life and exacerbating physical, cognitive, and metabolic dysfunctions. A multidisciplinary approach is essential to address these complex issues. CASE PRESENTATION: A 17-year-old Hispanic male with juvenile Huntington disease and a body mass index of 44 kg/m

conclusionThis case illustrates the ethical considerations and challenges of managing severe obesity in juvenile Huntington disease. The decision to proceed with bariatric surgery prioritized improving quality of life, given the patient's limited life expectancy. The use of a multimodal treatment approach, including semaglutide and laparoscopic sleeve gastrectomy, significantly improved both physical health and psychosocial well-being. This case highlights the importance of shared decision-making in managing complex obesity cases in pediatric populations with neurodegenerative diseases.

Indexed as

Bariatric SurgeryGlucagon-Like PeptidesHuntington DiseaseObesity, MorbidPediatric ObesityAdolescentBody Mass IndexGlucagon-Like Peptide 1HumansMaleQuality of LifeSemaglutideTreatment OutcomeGlucagon-Like Peptide 1Glucagon-Like PeptidesSemaglutideCase reportJuvenile Huntington diseaseMetabolic and bariatric surgeryPediatric obesitySemaglutide

Identifiers

PMID41121434
PMCPMC12538795

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.