Evidence map›Paper›PMID 41121412›Full record

Trial reportCritical care (London, England)2025

Diagnostic performance of a 250-ml net ultrafiltration challenge to identify risk of preload-dependence in critically ill patients undergoing continuous renal replacement therapy: a randomized, cross-over trial.

Charlotte Biscarrat, Guillaume Deniel, Matthieu Chivot, Hodane Yonis, Louis Chauvelot, Mehdi Mezidi, Jean-Christophe Richard, Laurent Bitker

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Critical care (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Charlotte BiscarratService de Médecine Intensive - Réanimation, Hôpital de La Croix Rousse, Hospices Civils de Lyon, 103, Grande Rue de La CroixRousse, 69004, Lyon, France.
Guillaume DenielService de Médecine Intensive - Réanimation, Hôpital de La Croix Rousse, Hospices Civils de Lyon, 103, Grande Rue de La CroixRousse, 69004, Lyon, France.
Matthieu ChivotService de Médecine Intensive - Réanimation, Hôpital de La Croix Rousse, Hospices Civils de Lyon, 103, Grande Rue de La CroixRousse, 69004, Lyon, France.
Hodane YonisService de Médecine Intensive - Réanimation, Hôpital de La Croix Rousse, Hospices Civils de Lyon, 103, Grande Rue de La CroixRousse, 69004, Lyon, France.
Louis ChauvelotService de Médecine Intensive - Réanimation, Hôpital de La Croix Rousse, Hospices Civils de Lyon, 103, Grande Rue de La CroixRousse, 69004, Lyon, France.
Mehdi MezidiService de Médecine Intensive - Réanimation, Hôpital de La Croix Rousse, Hospices Civils de Lyon, 103, Grande Rue de La CroixRousse, 69004, Lyon, France.
Jean-Christophe RichardService de Médecine Intensive - Réanimation, Hôpital de La Croix Rousse, Hospices Civils de Lyon, 103, Grande Rue de La CroixRousse, 69004, Lyon, France.
Laurent BitkerService de Médecine Intensive - Réanimation, Hôpital de La Croix Rousse, Hospices Civils de Lyon, 103, Grande Rue de La CroixRousse, 69004, Lyon, France. laurent.bitker@chu-lyon.fr.ORCID https://orcid.org/0000-0002-4698-053X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDuring continuous renal replacement therapy (CRRT), preload-independent patients risk of becoming preload-dependent in case of excessive net ultrafiltration (UF MATERIALS AND

methodsWe conducted a single-center, randomized, cross-over trial, enrolling adult patients with CRRT, calibrated continuous cardiac index (CCI) monitoring, and preload-independent at time of enrolment. The diagnostic test consisted of 250-ml UF

resultsWe included 20 patients, comprising 36 UF

conclusionsA 250-ml UF

Indexed as

Continuous Renal Replacement TherapyCritical IllnessAgedCross-Over StudiesFemaleHumansMaleMiddle AgedUltrafiltrationAcute circulatory failureCardiac outputNet ultrafiltrationPassive leg raisingPreload-dependencePulse contour analysisRenal replacement therapy

Identifiers

PMID41121412
PMCPMC12541968

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.