ReviewJournal of cardiothoracic surgery2025
Perspectives on the gut microbiota in patients with non-small cell lung cancer-Two-Sample Mendelian Randomization combined with bibliometric analysis (2001-2023).
Review in Journal of cardiothoracic surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Bacterial taxa associated with lung cancer cases in Southeast Asians: a pilot case-control study.Cellular oncology (Dordrecht, Netherlands) · 2026Article
- Comment on "Robotic excision of choledochal cysts with Roux-en-Y hepatico-jejunostomy in children: surgical technique, experience and outcomes".Journal of robotic surgery · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to investigate the relationship between gut microbiota and non-small cell lung cancer (NSCLC) using bibliometric analysis and Two-Sample Mendelian Randomization (TSMR), and to elucidate the research trends and future directions in this field. The relationship between the intestinal microbiota and cancer has garnered growing scholarly interest; however, its precise role in non-small cell lung cancer (NSCLC) remains insufficiently understood.
methodsThis study conducted literature retrieval using the Web of Science Core Collection, performed bibliometric analysis and visualization using VOSviewer, CiteSpace, and the "bibliometrix" package in R software, and applied the Two-Sample Mendelian Randomization (TSMR) method to analyze the causal relationship between gut microbiota and NSCLC.
resultsThe study found a total of 171 research papers focusing on the gut microbiota of non-small cell lung cancer patients from 2001 to 2023. Through bibliometric analysis, it examined the country and institution distribution, citing and cited journals, authors and co-cited authors, as well as identified significant citation bursts. The Two-Sample Mendelian Randomization analysis confirmed a significant association between Aminococcaceae abundance and non-small cell lung cancer, lung adenocarcinoma, and lung squamous cell carcinoma, suggesting its potential role as a low-risk factor.
conclusionsThis study identified an association between gut microbiota and non-small cell lung cancer, suggesting a potential risk-lowering effect of Aminococcaceae. However, further large-scale and high-quality research is needed to comprehensively investigate the causal relationship between gut microbiota and non-small cell lung cancer, taking into account the complex interactions between gut microbiota and the host, in order to better understand the pathogenesis of NSCLC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.