Evidence map›Paper›PMID 41121305›Full record

ReviewWorld journal of surgical oncology2025

The multifaceted roles of ribosomal P complex in cancer.

Bokang Yan, Jiaxing Guo, Weiwei Lai, Yuanbing Chen, Zuli Wang, Yuanhao Peng, Shi Chang

Abstract readReview
In one paragraph

Review in World journal of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Experimental and therapeutic medicine · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bokang YanInstitute of Large-scale Scientific Facility and Centre for Zero Magnetic Field Science, Beihang University, Beijing, China.
Jiaxing GuoDepartment of Hematology, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, Hunan, China.
Weiwei LaiHunan Provincial Key Laboratory of Pediatric Orthopedics, The Affiliated Children's Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
Yuanbing ChenDepartment of Neurosurgery, Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zuli WangCenter for Tissue Engineering and Stem Cell Research, Guizhou Medical University, Guiyang, Guizhou, China.
Yuanhao PengNHC Key Laboratory of Carcinogenesis, Cancer Research Institute, School of Basic Medicine, Central South University, Changsha, Hunan, China.
Shi ChangClinical Research Center For Thyroid Disease In Hunan Province, Changsha, Hunan, China. changshixiangya@163.com.

Funding

National Key Research and Development Program of China 2023YFC2507605National Natural Science Foundation of China 82371602Opening fundings of Hunan Provincial Key Laboratory of Pediatric Orthopedics 2023TP1019Special Funding for the Construction of Innovative Provinces in Hunan 2020SK4003
6 · The paper itself

Abstract

The ribosomal P complex, a flexible lateral stalk structure of the ribosomal large subunit, consists of the RPLP0, RPLP1, and RPLP2 proteins, and is essential for the elongation phase of protein biosynthesis. Notably, RPLP proteins have been implicated in various pathological conditions, including autoimmune disorders, degenerative diseases, while recent studies have elucidated their biological functions and underlying mechanisms in cancer. This review summarizes the structural and functional aspects of ribosomal stalk proteins, their expression levels across different cancers, and their impact on cancer progression. Additionally, we describe the molecular networks involving these proteins and how their regulatory mechanisms contribute to the hallmark characteristics of cancer phenotypes. Targeting RPLP proteins represents a novel strategy for achieving better treatment outcome of cancer patients in the future.

Indexed as

NeoplasmsRibosomal ProteinsRibosomesHumansProtein BiosynthesisRibosomal ProteinsCancerOncogeneRibosomal p complexRPLP0RPLP1RPLP2

Identifiers

PMID41121305
PMCPMC12539146

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.