Evidence map›Paper›PMID 41121278›Full record

ArticleJournal of translational medicine2025

Macrophage dynamics and the role of TREM2 at the oral mucosal barrier.

Taiana C Leite, Jiamiao Chen, Alexander A Diacou, Sangmin Park, Andrew H Jheon, Jie Yin, Quinn T Easter, Nicholas F Fitz, Kevin M Byrd, Daniel R Clark

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Taiana C LeiteDepartment of Periodontics and Preventive Dentistry, School of Dental Medicine, University of Pittsburgh, 507 Salk Pavilion, 335 Sutherland Dr, Pittsburgh, PA, 15213, USA.
Jiamiao ChenCenter for Craniofacial Regeneration, School of Dental Medicine, University of Pittsburgh, Salk Pavilion, 335 Sutherland Dr, Pittsburgh, PA, 15213, USA.
Alexander A DiacouCenter for Craniofacial Regeneration, School of Dental Medicine, University of Pittsburgh, Salk Pavilion, 335 Sutherland Dr, Pittsburgh, PA, 15213, USA.
Sangmin ParkCenter for Craniofacial Regeneration, School of Dental Medicine, University of Pittsburgh, Salk Pavilion, 335 Sutherland Dr, Pittsburgh, PA, 15213, USA.
Andrew H JheonDepartment of Orthodontics, School of Dental Medicine, University of Pittsburgh, Salk Hall, 335 Sutherland Dr, Pittsburgh, PA, 15213, USA.
Jie YinDepartment of Orthodontics, School of Dental Medicine, University of Pittsburgh, Salk Hall, 335 Sutherland Dr, Pittsburgh, PA, 15213, USA.
Quinn T EasterDepartment of Oral and Craniofacial Molecular Biology, Virginia Commonwealth University, 520 North 12th Street, Richmond, VA, 23298, USA.
Nicholas F FitzDeparment of Environmental and Occupational Health, School of Public Health, University of Pittsburgh, 130 DeSoto St., Public Health Building, Pittsburgh, PA, 15261, USA.
Kevin M ByrdDepartment of Oral and Craniofacial Molecular Biology, Virginia Commonwealth University, 520 North 12th Street, Richmond, VA, 23298, USA.
Daniel R ClarkDepartment of Periodontics and Preventive Dentistry, School of Dental Medicine, University of Pittsburgh, 507 Salk Pavilion, 335 Sutherland Dr, Pittsburgh, PA, 15213, USA. daniel.clark@pitt.edu.ORCID 0000-0003-3453-6498

Funding

The impact of the aging immune system on periodontal diseaseK08DE029505 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CLARK, DANIEL R. · 2020 to 2024
$913k
Foundation for the National Institutes of Health K08DE029505Foundation for the National Institutes of Health R01AG075069NIDCR NIH HHS K08 DE029505
6 · The paper itself

Abstract

backgroundMacrophages have a critical role in mucosal barrier immunity, demonstrating dynamic phenotypes that promote and resolve inflammation. However, the regulation of this polarization is not fully understood. Triggering receptor expressed on myeloid cells 2 (TREM2) is an immunoregulatory receptor expressed on macrophages. The role of TREM2 in mucosal immunity has not been previously studied. Our objective was to investigate TREM2 on macrophages during periodontal disease (PD), a chronic inflammatory condition affecting the oral mucosa.

methodsPD was induced using a ligature method in wild-type (WT) and TREM2

resultsWe demonstrated TREM2 expression on oral mucosal macrophages, and the proportion of TREM2+ macrophages significantly increased during resolution of PD and decreased during active PD. Analysis of TREM2

conclusionThis study improves our understanding of macrophage polarization and introduces TREM2 as an important immunoregulator in the oral mucosa.

Indexed as

MacrophagesMembrane GlycoproteinsMouth MucosaReceptors, ImmunologicAnimalsCytokinesHumansInflammationMaleMiceMice, Inbred C57BLMice, KnockoutPeriodontal DiseasesCytokinesMembrane GlycoproteinsReceptors, ImmunologicTREM2 protein, humanTrem2 protein, mouseInflammationMacrophagesMiceOral mucosaPeriodontal disease

Identifiers

PMID41121278
PMCPMC12538780

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.