Evidence map›Paper›PMID 41121238›Full record

ArticleClinical epigenetics2025

DNA methylation: a potential mediator between air pollution exposures and asthma control.

My-Nhi Nguyen, Katelyn Queen, Frank D Gilliland, Sung Chun, Benjamin Raby, Joshua Millstein

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In one paragraph

Article in Clinical epigenetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

My-Nhi NguyenDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA. ngocmynh@usc.edu.
Katelyn QueenDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
Frank D GillilandDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
Sung ChunDivision of Pulmonary Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Benjamin RabyDivision of Pulmonary Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Joshua MillsteinDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.

Funding

Statistical Methods for Integrative Genomics in CancerP01CA196569 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI David V Conti · 2016 to 2026
$25.5M
The Integrative Genomics of Acute Asthma ControlR01HL118455 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MILLSTEIN, JOSHUA, RABY, BENJAMIN ALEXANDER · 2014 to 2024
$6.5M
NCI NIH HHS P01 CA196569NHLBI NIH HHS R01 HL118455NHLBI NIH HHS R01HL118455
6 · The paper itself

Abstract

backgroundExposure to air pollution is known to contribute to the development and exacerbation of asthma symptoms, impacting respiratory health through complex, not yet fully understood biological mechanisms. It is hypothesized that DNA methylation (DNAm) changes triggered by air pollutants may mediate these effects on asthma symptom control.

objectivesWe aimed to investigate the effects of air pollution on DNAm in peripheral blood and asthma control. We also explored whether DNAm could potentially mediate the relationship between air pollution exposure and asthma control.

methodsThis study included 651 participants with asthma exposed to ambient air pollutants, NO

resultsExposure to short-term PM DISCUSSION: These findings suggest that air pollution-associated changes in DNA methylation may affect asthma control for some loci, thus help elucidate underlying mechanisms in asthmatic patients. These epigenetic alterations highlight potential targets for understanding the pathophysiology of asthma due to air pollution. While our findings suggest possible links between air pollution, DNA methylation, and asthma control, more evidence is needed to establish causal relationships and unravel the complexities of these connections.

Indexed as

Air PollutantsAir PollutionAsthmaDNA MethylationEnvironmental ExposureAdultCpG IslandsEpigenesis, GeneticFemaleGenome-Wide Association StudyHumansMaleMiddle AgedParticulate MatterAir PollutantsParticulate MatterAir pollutionAsthmaCausal mediationDNA methylation

Identifiers

PMID41121238
PMCPMC12542048

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.