Observational studyPediatric rheumatology online journal2025
Efficacy and safety of telitacicept in children with IgA vasculitis and IgA vasculitis nephritis: a single-center retrospective study.
Observational study in Pediatric rheumatology online journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Immune-mediated renal injury and cardiometabolic risk in IgA nephropathy: clinical evidence on telitacicept from a scoping review.Frontiers in nutrition · 2026Pooled it
- Update on IgA nephropathy: implications for treatment in IgA vasculitis: a guide for rheumatologists.Current opinion in rheumatology · 2026Review
- Renal Involvement in Pediatric Small-Vessel Vasculitis: A Comprehensive Review of Clinical Impact, Diagnosis, and Management.Medical sciences (Basel, Switzerland) · 2026Review
- Novel use of telitacicept in primary immune thrombocytopenia: a case report.BMC pediatrics · 2026Article
- Telitacicept for childhood HSPN: A prospective self-controlled study.Clinical rheumatology · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundImmunoglobulin A vasculitis (IgAV) is the most common childhood vasculitis and can lead to immunoglobulin A vasculitis nephritis (IgAVN) in severe cases, potentially progressing to kidney failure in a subset of children. Safer and more effective treatments are needed to improve outcomes in these children. This study aimed to evaluate the efficacy and safety of telitacicept in the treatment of children with IgAV and IgAVN.
methodsThis is a single-center, retrospective observational study of twenty four children with IgAV or IgAVN who received telitacicept treatment, and thirty matched children with IgAVN who only received conventional treatment were taken as the control group for children with IgAVN who received telitacicept treatment in acute phase. The treatment response was evaluated through urine protein, serum albumin, eGFR and serum immunoglobulin levels, and data was analyzed at telitacicept initiation and at 4, 12, 24 and 36 weeks after treatment.
resultsA total of twenty four children (thirteen boys and eleven girls) with IgAV (n = 5) and IgAVN (n = 19, comprising ten acute and nine chronic cases) were enrolled. All children with IgAV experienced improvement of skin, joint, and gastrointestinal symptoms after telitacicept treatment, with no kidney involvement during follow-up. In children with IgAVN, the urinary protein-to-creatinine ratio (UPCR) significantly decreased at 36 weeks compared to baseline (P < 0.05) in both acute and chronic groups, while estimated glomerular filtration rate (eGFR) remained stable (P > 0.05). In addition, the dose of steroids administered during the treatment with telitacicept was significantly reduced, the acute IgAVN group exhibited significantly greater steroid reduction between weeks 4 and 24 compared with the controls group (P < 0.05). Furthermore, serum immunoglobulin levels (IgA, IgG) significantly decreased 12 weeks after telitacicept treatment (P < 0.01), and no other adverse reactions observed.
conclusionTelitacicept appears to be a promising therapy for children with IgAV and IgAVN, effectively inducing proteinuria remission, improving systemic symptoms, and reducing the use of steroids, with favorable safety.
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