Evidence map›Paper›PMID 41121206›Full record

ArticleBMC medical informatics and decision making2025

A standard-based taxonomy of features that affect user response to clinical decision support alerts.

Siru Liu, Allison B McCoy, Dean F Sittig, Josh F Peterson, Thomas A Lasko, Adam Wright

Abstract read
In one paragraph

Article in BMC medical informatics and decision making, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Siru LiuDepartment of Biomedical Informatics, Vanderbilt University Medical Center, 2525 West End Ave #1475, Nashville, TN, 37212, USA. siru.liu@vumc.org.
Allison B McCoyDepartment of Biomedical Informatics, Vanderbilt University Medical Center, 2525 West End Ave #1475, Nashville, TN, 37212, USA.
Dean F SittigDepartment of Clinical and Health Informatics, University of Texas Health Science Center, Houston, TX, USA.
Josh F PetersonDepartment of Biomedical Informatics, Vanderbilt University Medical Center, 2525 West End Ave #1475, Nashville, TN, 37212, USA.
Thomas A LaskoDepartment of Biomedical Informatics, Vanderbilt University Medical Center, 2525 West End Ave #1475, Nashville, TN, 37212, USA.
Adam WrightDepartment of Biomedical Informatics, Vanderbilt University Medical Center, 2525 West End Ave #1475, Nashville, TN, 37212, USA.

Funding

Safety Promotion through Early Event Detection in the Elderly (SPEEDe)R01AG062499 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WRIGHT, ADAM T · 2019 to 2023
$3.5M
Optimizing Clinical Decision Support Alerts Using Explainable Artificial Intelligence (XAI)R00LM014097 · NLM · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LIU, SIRU · 2023 to 2024
$498k
Optimizing Clinical Decision Support Alerts Using Explainable Artificial Intelligence (XAI)K99LM014097 · NLM · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LIU, SIRU · 2022 to 2022
$90k
NIA NIH HHS R01 AG062499NIH HHS K99LM014097NIH HHS R01AG062499NLM NIH HHS K99 LM014097NLM NIH HHS R00 LM014097
6 · The paper itself

Abstract

objectiveThe objective of this work is to develop a standard-based taxonomy of features that might affect user response to alerts using evidence from literature and public alert logic repositories.

methodsWe developed a taxonomy of features using multiple sources: (1) the Agency for Healthcare Research and Quality (AHRQ) CDS Connect Repository, (2) alert logic from commercial electronic health record (EHR) customers, and (3) published literature. Three categories (patient, provider, environment/context) were used a priori to develop the taxonomy. The final taxonomy was mapped to the Fast Healthcare Interoperability Resources (FHIR) standard for development of standardized CDS services.

resultsAggregating potential features extracted from three data sources, we identified 95 unique features, which we then mapped to the FHIR standard, encompassing 24 FHIR resources. The common features differed depending on the knowledge source. In the AHRQ public alert repository, frequently occurring features were observations in flowsheets, procedures, diagnoses, medications, and patient age. On the other hand, the commercial EHR customers primarily presented features such as diagnosis type, patient age, diagnosis grouper, diagnosis, medication value set. Literature-based insights revealed that provider type, medication, patient age, alert severity, and medication dose were the most common features.

conclusionThis study demonstrated a standard-based taxonomy of features that could impact user responses to CDS alerts, bridging insights from academic studies and industry practices. The taxonomy stands as a foundational tool, guiding the CDS development, implementation, and evaluation, with the overarching goal of improving user acceptance and healthcare quality.

Indexed as

Decision Support Systems, ClinicalElectronic Health RecordsHealth Information InteroperabilityMedical Order Entry SystemsClassificationHumansAlert fatigueClinical decision supportHealth personnelTaxonomy

Identifiers

PMID41121206
PMCPMC12542428

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.