SynthesisBMC psychiatry2025
Association between anxiety disorders and medication adherence in patients with cardiovascular disease: a systematic review and meta-analysis of observational studies.
Synthesis in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Interoception as a Mechanism Linking Anxiety, Cardiovascular Disease, and their Co-Occurrence.Current cardiology reports · 2026Review
- Health anxiety, mental defeat and fear of illness recurrence and progression following a cardiac event: Implications for cardiac rehabilitation.British journal of health psychology · 2026Article
- Article
- Intelligent mobile health management for the risk of gastrointestinal bleeding in anticoagulated patients with cardiovascular disease.Revista da Escola de Enfermagem da U S P · 2026Observational
- Metamemory and Emotional Contributions to the Relationship Between Cognitive Function and Medication Adherence in H-Type Hypertension: A Cross-Sectional Mediation Analysis.Patient preference and adherence · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe management of cardiovascular (CV) diseases is considerably hindered by the presence of anxiety disorders, which act as a significant barrier to medication adherence. This systematic review and meta-analysis aim to synthesize existing evidence on the relationship between anxiety and medication adherence in individuals with CV diseases.
methodsA systematic search was conducted across five major databases from inception to 2025. The methodological quality of the included studies was assessed using the National Institutes of Health (NIH) quality assessment tool. A random-effects meta-analysis was conducted utilizing Comprehensive Meta-Analysis software (version 3), with with p < 0.05 indicating significance.
resultsA total of 23 studies were selected, including 18 with cross-sectional and five with a longitudinal study design. The combined sample size was 72,815 participants, with an average age of 60.7 years and 51.7% were male participants. Majority of studies (n = 15) reported a negative association between anxiety and cardiovascular (CV) medication adherence. Meta-analysis (n = 20) further supported this overall negative association (SMD = -1.087, 95% CI [-1.469, -0.705], p < 0.001) which was also evident across clinical subgroups: hypertension (SMD = -0.648, 95% CI [-1.293, -0.004], p = 0.049), congestive heart failure (SMD = -0.51, 95% CI [-0.92, -0.10], p = 0.02), and ischemic heart disease (SMD = -2.322, 95% CI [-3.498, -1.146], p < 0.001).
conclusionThis review primarily contributes to the understanding of negative association between anxiety and medication adherence in the context of CV diseases. However, the predominance of cross-sectional designs, and substantial heterogeneity necessitate cautious interpretation of these findings.
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