Trial reportBMC psychiatry2025
Moderating role of familial relationships in the efficacy of rTMS intervention on cognitive function in patients with schizophrenia.
Trial report in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03774927 (A Randomized, Double-blind Sham-controlled Trial of High Frequency rTMS for Cognitive Impairments in Chronic Schizophrenia Patients), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized, Double-blind Sham-controlled Trial of High Frequency rTMS for Cognitive Impairments in Chronic Schizophrenia Patients
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt has been hypothesized that rTMS improves cognitive performance in SCZ by altering neuronal activity through magnetic field pulses. However, these findings were controversial. The present study examined whether familial relationships impacted the effect of rTMS targeting the left DLPFC on cognitive function improvement in patients with SCZ.
methodsA total of 84 SCZ patients were randomly allocated to the active rTMS or sham rTMS groups and received a 6-week intervention session. Patients were followed up at the end of the 24th week. Cognitive functions were evaluated at baseline and at the end of the 2nd, 6th, and 24th weeks. Patients' relationships with their family members were also evaluated.
resultsSignificant interactions of time × treatment on immediate memory and total scores were observed in patients with SCZ treated with rTMS. Active rTMS stimulation showed a beneficial effect on immediate memory in SCZ. In addition, we found that after controlling for confounding factors, patients with positive familial relationships experienced greater improvements in immediate memory after rTMS than those with negative relationships. More importantly, linear regression analysis revealed that familial relationship was a predictor of immediate memory improvement following rTMS intervention.
conclusionsOur results reveal that familial relationships significantly influence the outcome of rTMS treatment in patients with SCZ. Relative to patients with negative familial relationships, those with positive relationships showed greater cognitive improvement.
trial registrationClinicalTrials.gov, NCT03774927, registered on 20,181,211.
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