Observational studyBMC cancer2025
Real-world evidence in localized and locally advanced prostate cancer: applying artificial intelligence to electronic health records.
Observational study in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- From electronic health records to real-world evidence: Savana Next-Generation Registry digital solution.ESMO real world data and digital oncology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo provide real-world evidence of the clinical characteristics and outcomes of localized and locally advanced prostate cancer patients (LPC/LAPC). MATERIALS &
methodsObservational and retrospective analysis using secondary data from electronic health records (EHR) of prostate cancer (PC) patients in eight Spanish hospitals (2014–2018). Data was extracted and analyzed using EHRead® technology, based on natural language processing and machine learning. LPC/LAPC patients were included and stratified by risk and by first treatment received.
resultsTwenty-two thousand one hundred sixty-six PC patients were identified,14,434 (65.1%) were classified as LPC/LAPC. Among them, 5,331 incident patients with sufficient data were selected for outcome analysis (real world overall survival [rwOS], metastasis and event free survival [MFS, EFS]) and were followed for a median time of 2.3 years. 36.5% were classified as LPC intermediate risk (IR), 26.0% LPC high risk (HR), 7.3% LPC low risk (LR), 5.9% LAPC, and 24.2% unknown risk. First treatment received was radiotherapy (RT) in 40.7%, radical prostatectomy (RP) in 37.1%, active surveillance (AS)/watchful waiting (WW) in 6.4%, brachytherapy (BT) in 4.2%, and androgen deprivation therapy monotherapy (ADT only) in 3.3%. rwOS and MFS worsened as risk increased. Patients treated with ADT only presented the worst baseline characteristics, showing limited clinical outcomes. The 36-month rwOS was 91% for LAPC patients, 93% for HR-LPC, 97% for IR-LPC, and 98% for LR-LPC.
conclusionsDespite using treatment with curative intent, patients experienced oncological events within a median of less than three years post-diagnosis. Our findings emphasize the need for risk stratification, and proactive strategies to improve clinical outcomes.
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