ArticleBMC surgery2025
Comparison of identification of sentinel lymph nodes between ICG vs methylene blue in v notes staging surgery for endometrial cancer.
Article in BMC surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Vaginal Natural Orifice Transluminal Endoscopic Surgery (vNOTES) in Patients with Gynecological Malignancies: A Systematic Review.Journal of clinical medicine · 2026Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to assess the comparative effectiveness of indocyanine green and methylene blue in the marking and identification of sentinel lymph nodes during sentinel lymph node biopsy procedures in patients diagnosed with endometrial cancer undergoing staging surgery through vaginal natural-orifice transluminal endoscopic surgery.
methodsIn this retrospective cohort study conducted at a tertiary center, we analyzed 80 patients with endometrial cancer who underwent vaginal natural orifice transluminal endoscopic staging surgery. Patients were classified into two cohorts based on the tracer used for sentinel lymph node sentinel lymph node mapping: indocyanine green (n = 40) or methylene blue (n = 40). The primary endpoints, including sentinel lymph node detection rates (overall and bilateral) and number of nodes retrieved, along with surgical outcomes, were compared between the groups.
findingsEighty patients (indocyanine green group, n = 40; methylene blue group, n = 40) were included in the study. The vaginal natural orifice transluminal endoscopic surgery identification rate was significantly higher in the indocyanine green group (95%) than in the methylene blue group (82.5%) (p = 0.045). The mean number of sentinel lymph nodes identified in the indocyanine green group (3.2 ± 1.1) was significantly higher than that in the methylene blue group (2.5 ± 0.9) (p = 0.021). The rate of bilateral vaginal natural orifice transluminal endoscopic surgery identification was higher in the indocyanine green group (80%) than in the methylene blue group (65%); however, the difference was not statistically significant (p = 0.112). Surgical time, blood loss, and complication rates were similar between the two groups. Histopathological examination revealed a similar number of positive sentinel lymph nodes in both the groups.
conclusionIn the context of sentinel lymph node biopsy for staging surgery and natural orifice transluminal endoscopic surgery for endometrial cancer, indocyanine green has demonstrated a superior sentinel lymph node identification rate and a higher yield of sentinel lymph nodes compared to methylene blue. Given the advantage of real-time imaging, indocyanine green has emerged as a promising agent for sentinel lymph node biopsy in minimally invasive approaches, such as vaginal natural orifice transluminal endoscopic surgery.
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