Evidence map›Paper›PMID 41120949›Full record

ArticleBMC infectious diseases2025

Serological and molecular detection of hepatitis C virus in Amran governorate, Yemen.

Ali Ahmed Al-Hadheq, Bashir Ahmed Al-Ofairi, Adam Dawoud Abakar, Azhari Mohammed, Wadhah Hassan Edrees, Wadee Abdullah Al-Shehari, Ahmed Salem Al-Jendy, Yosria Mohammed Elsiddig, Abdulrahman Abdullah Humaid

Abstract read
In one paragraph

Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ali Ahmed Al-HadheqDepartment of Biology, Faculty of Applied Science and Humanities, Amran University, Amran, Yemen. alhatheqali@gmail.com.ORCID http://orcid.org/0009-0004-9541-5563
Bashir Ahmed Al-OfairiDepartment of Biological Sciences, Faculty of Sciences, Sana'a University, Sana'a, Yemen.ORCID http://orcid.org/0000-0002-7859-9944
Adam Dawoud AbakarDepartment of Medical Microbiology, Faculty of Medical Laboratory Sciences, Gezira University, Wad Medani, Sudan.
Azhari MohammedDepartment of Medical Microbiology, Faculty of Medical Laboratory Sciences, Gezira University, Wad Medani, Sudan.
Wadhah Hassan EdreesMedical Microbiology Department, Faculty of Applied Sciences, Hajjah University, Hajjah, Yemen.ORCID http://orcid.org/0000-0002-7799-0466
Wadee Abdullah Al-ShehariMedical Microbiology Department, Faculty of Medical Sciences, Ibb University, Ibb, Yemen.ORCID http://orcid.org/0000-0002-3375-0559
Ahmed Salem Al-JendyDepartment of Medical Laboratory technology Al-Ma,afer Community College, Taiz, Yemen.
Yosria Mohammed ElsiddigDepartment of Medical Microbiology, Faculty of Medical Laboratory Sciences, Gezira University, Wad Medani, Sudan.
Abdulrahman Abdullah HumaidDepartment of Biological Sciences, Faculty of Sciences, Sana'a University, Sana'a, Yemen.ORCID http://orcid.org/0000-0002-2606-8922

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHepatitis C virus (HCV) is a blood-borne virus that causes acute or chronic hepatitis, depending on its severity, and its development leads to cirrhosis or hepatocellular carcinoma. This study aimed to detect HCV using the serological and molecular techniques among blood donors and clinical visitors in Amran governorate, Yemen.

methodsA total of 800 blood specimens were collected from blood donors (500 specimens) and clinical visitors (300 specimens). Blood specimens were screened for HCV using an immunochromatographic technique (ICT) and the enzyme-linked immunosorbent assay (ELISA), and the final positive cases for HCV were confirmed by nested polymerase chain reaction (nPCR).

resultsOut of 800 specimens, only 21 (2.6%) were reported as positive for HCV by molecular analysis. According to diagnostic techniques, 18 (2.3%), 22 (2.7%), and 21 (2.6%), respectively, of specimens were reported as positive for HCV by ICT, ELISA, and PCR techniques. Moreover, a higher rate of HCV was found among participants aged 21-30 years (4.3%), females (2.5%), urban residents (2.7%), single individuals (3.1%), and uneducated individuals (6.1%). In addition, the proportion of HCV was significantly higher among participants with a family history of HCV infection (11.6%), previous surgery (30.8%), no blood transfusion (2.9%), prior cupping (9.1%), and perinatal injury (4.6%).

conclusionThis finding indicates that the prevalence rate of HCV infection in the study area is high. To protect the general public from the spread of HCV infection, it is essential to develop a public health approach including surveillance and monitoring, strengthening infrastructure, training healthcare workers in early detection and treatment of cases, and increasing public awareness.

Indexed as

HepacivirusHepatitis CAdolescentAdultAgedBlood DonorsChildEnzyme-Linked Immunosorbent AssayFemaleHumansMaleMiddle AgedPolymerase Chain ReactionYemenYoung AdultBlood donorsChronic hepatitisELISAHepatitis c virusPCRYemen

Identifiers

PMID41120949
PMCPMC12542161

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.