Evidence map›Paper›PMID 41120939›Full record

ArticleBMC infectious diseases2025

Spatial clusters of dominant lineages of uropathogenic Escherichia coli in a community dwelling patient population.

Cheyenne Belmont, Pushkar Inamdar, Salma Shariff-Marco, Amina Gul, Alison J Huang, Henry F Chambers, Eva Raphael

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Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Cheyenne BelmontDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
Pushkar InamdarDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
Salma Shariff-MarcoDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
Amina GulDepartment of Pathology, Khyber Medical College, Peshawar, Pakistan.
Alison J HuangDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Henry F ChambersDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Eva RaphaelDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA. Eva.Raphael@ucsf.edu.

Funding

UCSF-Kaiser Urological Epidemiology Research Career Development ProgramK12DK111028 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, ALISON · 2016 to 2025
$5.3M
Patient-Oriented Research and Mentoring in Genitourinary AgingK24AG068601 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Alison Huang · 2020 to 2026
$1.2M
Community-onset urinary tract infections caused by extended-spectrum beta-lactamase-producing Escherichia coli in women of diverse backgroundsK23AI166030 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Eva Raphael · 2022 to 2026
$1.1M
NIAID NIH HHS K23 AI166030NIA NIH HHS K24 AG068601NIDDK NIH HHS K12 DK111028NIH HHS K23AI166030
6 · The paper itself

Abstract

introductionAntimicrobial resistance (AMR) is a major public health concern, especially in the clinical management of urinary tract infections (UTIs). While use of antimicrobial agents selects for AMR bacterial strains, it remains unclear if this factor alone drives the prevalence of UTIs caused by AMR uropathogenic Escherichia coli (UPEC) in community settings. Local prevalence of AMR UTIs may be largely influenced by spatial clusters of already-resistant sequence types within a community rather than by the initial selection of resistant strains by antimicrobial agents. The goal of this study is to examine geospatial clustering of UTI by common AMR UPEC ST lineages.

methodsWe collected 551 UPEC isolates from patients receiving care in a San Francisco public healthcare system from April to September 2019. Isolates underwent multiplex PCR for rapid identification of pandemic UPEC STs (ST69, ST73, ST95, ST131) and were linked with electronic health records data. We conducted Global Moran's I and Local Moran's I to detect spatial clusters of each pandemic ST lineage.

results45% of UPEC isolates (N = 247) were identified as pandemic ST lineages. ST131 comprised 72 (29%) of the pandemic ST lineages and contributed the most multidrug resistant isolates (resistant to ≥ 3 classes of antibiotics) (N = 29). Spatial clusters of ST95, ST131 and ST69 (p < 0.001, p < 0.001, p = 0.008, respectively) were identified.

conclusionWe found spatial clusters of community-onset bacteriuria caused by predominant ST lineages, suggesting common-source outbreaks. This novel approach may inform future surveillance efforts to reduce community transmission of AMR UPEC and provides the basis for future investigations of environmental risk factors for AMR UTI.

Indexed as

Escherichia coli InfectionsUrinary Tract InfectionsUropathogenic Escherichia coliAdultAgedAged, 80 and overAging in PlaceAnti-Bacterial AgentsCluster AnalysisDrug Resistance, Multiple, BacterialFemaleHumansMaleMiddle AgedPrevalenceSan FranciscoAnti-Bacterial Agents

Identifiers

PMID41120939
PMCPMC12542483

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.