SynthesisBMC cardiovascular disorders2025
Evaluation of the efficiency of at least 24-hour observation of transition to oral diuretic therapy before discharge on 30-day outcomes in acute heart failure patients: a comparative systematic review and meta-analysis.
Synthesis in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Diuretic resistance during emergency treatment of acute heart failure: incidence and correlation with 30-day readmission.American journal of translational research · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundAcute heart failure (AHF) patients face high risks of readmission and mortality post-discharge. Transitioning from intravenous (IV) to oral (PO) diuretics before discharge is recommended to improve patient stability. However, the effectiveness of a prolonged observation period on oral diuretics (> 24 h) before discharge is still unclear.
objectiveThis systematic review and meta-analysis aimed to evaluate the effects of an extended (at least 24 h) oral diuretic response observation period prior to discharge on 30-day outcomes, including mortality, rehospitalization, and length of stay in patients with acute heart failure (AHF).
methodsA comprehensive literature search was conducted across multiple databases, including PubMed/Medline, Embase, and Cochrane, up to November 2024. The study followed the PRISMA guidelines and was registered with PROSPERO (CRD42024608663). Seven retrospective observational studies involving 14,417 AHF patients were included. The Newcastle-Ottawa Quality Assessment Scale was applied to assess the risk of bias.
resultsThe meta-analysis found no significant reduction in mortality (OR: 0.85; 95% CI [0.53-1.36]) or heart failure re-admissions (OR: 0.99; 95% CI[0.93-1.05]) for patients observed for at least 24 h after oral diuretic transition compared to those with shorter or no observation. All-cause readmission outcomes also showed no significant difference (OR: 1.02; 95% CI [0.71-1.47]). However, a longer LOS was observed in patients with extended observation (mean difference: 2.14 days; 95% CI [1.26-3.03]).
conclusionExtended, at least 24-hour observation after the transition to oral diuretics therapy was significantly associated with an increased LOS but not an improvement in 30-day mortality or readmission rates in AHF patients.
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