ArticleBMC microbiology2025
Gut microbiome alterations in IgG4-related ophthalmic disease.
Article in BMC microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- IgG4-related disease has a specific intestinal microbiota signature.EBioMedicine · 2026Article
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Authors and funding
9 authors.
Funding
Abstract
backgroundThis study aims to investigate the gut microbiome alterations in IgG4-related ophthalmic disease (IgG4-ROD) and explore the potential roles of serum IgE and IgG4 in this disease.
methodsIn this prospective study, we recruited a total of 34 participants, including 17 IgG4-ROD patients and 17 healthy controls (HC) from Beijing Tongren Hospital. Fecal and blood samples were collected and analyzed, including 16 S rRNA gene sequencing of fecal samples. We assessed alpha and beta diversity to identify microbial variations among IgG4-ROD and HC, IgG4+ and IgG4-, IgE + and IgE-, and hormone-treated and untreated groups. Correlation analyses between cytokines and microbial profiles were conducted to uncover novel insights into the pathogenesis of IgG4-ROD.
resultsSignificant differences in microbial composition were observed among subgroups. Patients with IgG4-ROD showed increases in Proteobacteria, Parvimonas, Novosphingobium, Shigella, and Allobaculum, along with decreased levels of Faecalibacterium, Barnesiella, and Weissella. The IgE + group exhibited an elevated abundance of Enterobacteriaceae, with several microbial changes overlapping between IgG4-ROD and IgE + individuals. Sphingomonas and Peptostreptococcaceae were more prevalent in the IgG4 + group, while Adlercreutzia and Acidimicrobiales were abundant in the IgG4- group. Furthermore, Ruminococcaceae were enriched in the HC and IgG4- groups. Pelomonas and Escherichia were increased in IgG4-ROD patients treated with glucocorticosteroids. Additionally, significant correlations were identified between several microbial taxa and serum cytokines such as IL-1β, IL-2, IFN-α, C3, and IgG4.
conclusionThe findings indicate gut dysbiosis in IgG4-ROD and suggest influential roles for serum IgE and IgG4, enhancing our understanding of microbial-clinical interactions in this disease.
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