MultiModalGraphics: an R package for graphical integration of multi-omics datasets.

Multimodal visualizations are essential for identifying and interpreting complex relationships in diverse, high-dimensional biological datasets. However, existing visualization tools often lack native capabilities for embedding explicit statistical and computational annotations, hindering effective quantitative interpretation. We introduce MultiModalGraphics, an R package designed specifically for creating annotated scatterplots and heatmaps of multi-omics and high-dimensional biological data. The package allows seamless embedding of statistical summaries such as fold-changes, p-values, q-values, and standard deviations, facilitating direct quantitative comparisons. MultiModalGraphics interoperates with Bioconductor packages including MultiAssayExperiment, limma, voom, and iClusterPlus, streamlining workflows from data preprocessing and differential expression analysis to visualization. Case studies on three distinct real-world multimodal datasets illustrate its practical utility. Source code, documentation, and example datasets are available via GitHub ( https://github.com/famanalytics0/MultiModalGraphics ) and under review for inclusion into Bioconductor.