A rare cystic and papillary variant of acinar cell carcinoma with liver metastasis and molecular analysis.

Meredith K Herman, Eric Chang, Jiaqi Shi

Abstract read

In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Meredith K Herman *Department of Pathology & Clinical Labs, University of Michigan, 2800 Plymouth Road, Building 35, Ann Arbor, MI, 48109, USA.ORCID http://orcid.org/0000-0002-6164-5836

Eric Chang *Department of Pathology & Clinical Labs, University of Michigan, 2800 Plymouth Road, Building 35, Ann Arbor, MI, 48109, USA.ORCID http://orcid.org/0009-0005-1202-1858

Jiaqi ShiDepartment of Pathology & Clinical Labs, University of Michigan, 2800 Plymouth Road, Building 35, Ann Arbor, MI, 48109, USA. jiaqis@med.umich.edu.ORCID http://orcid.org/0000-0003-4893-1587

Funding

Defining epigenetic signaling to reshape pancreatic tumor microenvironmentR37CA262209 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jiaqi Shi · 2022 to 2026

$2.3M

NCI NIH HHS R37 CA262209NCI NIH HHS R37CA262209

6 · The paper itself

Abstract

Acinar cell carcinoma (ACC) is a pancreatic neoplasm with histologic variants that pose significant diagnostic challenges. We report a 75-year-old man with a previously unreported cystic and papillary ACC metastatic to the liver. Histologically, the tumor exhibited cystic and papillary proliferations of epithelial cells with eosinophilic cytoplasm, prominent nucleoli, and frequent mitoses. Immunohistochemical analysis showed positivity for trypsin and BCL-10, confirming ACC. The cyst lining displayed both acinar and ductal features, suggesting origin from acinar cystic transformation with acinar-to-ductal metaplasia rather than a true intraductal neoplasm. Molecular studies identified NRAS, CTNNB1, and SMAD4 mutations. Despite reports of indolent behavior in similar variants, our patient developed peritoneal metastasis and died 2 years after surgery and chemotherapy, highlighting the potential for aggressive clinical behavior and the importance of distinguishing these tumors from benign cystic pancreatic neoplasms.

Indexed as

Acinar cystic transformationAcinar-to-ductal metaplasiaIntraductal cystic neoplasmNRAS mutationPancreatic ductal adenocarcinoma

Identifiers

PMID41120769

DOI10.1007/s00428-025-04315-y

PMCPMC12579383

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.