Evidence map›Paper›PMID 41120763›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2025

Automated bone age calculation is an independent predictor of vertebral fracture burden in Duchenne muscular dystrophy.

Kim Phung, Damian Rauch, Stefan Jackowski, Maya Scharke, Khaldoun Koujok, Mary-Ann Matzinger, Nazih Shenouda, Jacob L Jaremko, Nagwa Wilson, Ramy El Jalbout and 8 more

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Kim PhungDepartments of Pediatrics and Surgery, University of Ottawa, Children's Hospital of Eastern Ontario, Division of Endocrinology and Metabolism, Room 250H, 401 Smyth Road, Ottawa, ON, Canada.
Damian RauchThe Ottawa Pediatric Rare Bone Disease Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
Stefan JackowskiThe Ottawa Pediatric Rare Bone Disease Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
Maya ScharkeThe Ottawa Pediatric Rare Bone Disease Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
Khaldoun KoujokThe Ottawa Pediatric Rare Bone Disease Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
Mary-Ann MatzingerThe Ottawa Pediatric Rare Bone Disease Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
Nazih ShenoudaThe Ottawa Pediatric Rare Bone Disease Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
Jacob L JaremkoThe Ottawa Pediatric Rare Bone Disease Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
Nagwa WilsonThe Ottawa Pediatric Rare Bone Disease Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
Ramy El JalboutThe Ottawa Pediatric Rare Bone Disease Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
Rui SantosThe Ottawa Pediatric Rare Bone Disease Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
Nasrin KhanThe Ottawa Pediatric Rare Bone Disease Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
Mei WangThe Ottawa Pediatric Rare Bone Disease Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
Laura McAdamHolland Bloorview Kids Rehabilitation Hospital, Bloorview Research Institute, University of Toronto, Toronto, ON, Canada.
Hugh J McMillanThe Ottawa Pediatric Rare Bone Disease Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
Jinhui MaThe Ottawa Pediatric Rare Bone Disease Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
Kerry SiminoskiThe Ottawa Pediatric Rare Bone Disease Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
Leanne M WardDepartments of Pediatrics and Surgery, University of Ottawa, Children's Hospital of Eastern Ontario, Division of Endocrinology and Metabolism, Room 250H, 401 Smyth Road, Ottawa, ON, Canada. lward@cheo.on.ca.ORCID http://orcid.org/0000-0003-1557-9185

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone age (BA) assessments by BoneXpert were similar to BA evaluations by experienced radiologists in males with Duchenne muscular dystrophy (DMD). Furthermore, BA delay as determined by both radiologists and BoneXpert, and the BoneXpert-derived Bone Health Index Z-score (a surrogate for bone strength), were associated with spinal fragility. PURPOSE: To compare BA assessed by experienced radiologists versus BoneXpert in males with DMD and to evaluate the extent to which BA delay, and the BoneXpert-derived Bone Health Index (BHI, a proposed surrogate for bone strength), are associated with the Spinal Deformity Index (a measure of vertebral fracture [VF] burden).

methodsResults were compared for BA evaluated on 54 left-hand radiographs from patients with DMD (chronological age [CA] 11.6 ± 3.8 years; mean ± SD) by experienced radiologists versus BoneXpert. The relationships between BA delay (CA-BA), BHI, and the SDI were assessed.

resultsThe mean BA delays reported by radiologists (-1.9 ± 2.4 years) and BoneXpert (-1.8 ± 2.4 years) were similar (p = 0.138) with an intraclass correlation coefficient of 0.978 (95% confidence interval [CI], 0.961-0.987). Multivariable Poisson regression showed that every 1-year BA delay by BoneXpert was associated with a 1.5-fold (95% CI, 1.1-2.1; p = 0.009) increase in incidence rate ratio (IRR) for SDI, similar to radiologists (1.8; 95% CI, 1.3-2.5; p = 0.001). In a separate model, every 1.0 unit decrease in the BHI Z-score by BoneXpert was associated with a 2.9-fold (95% CI, 2.0-4.2; p < 0.001) increase in IRR for SDI.

conclusionBoneXpert provided BA results that were similar to those generated by radiologists in individuals with DMD and that retained the clinically relevant association between BA delay and VF. We also demonstrated that lower BHI Z-scores in individuals with DMD were associated with spinal fragility.

Indexed as

Age Determination by SkeletonMuscular Dystrophy, DuchenneOsteoporotic FracturesSpinal FracturesAdolescentBone DensityChildHand BonesHumansMaleBone ageBoneXpertDuchenne muscular dystrophyGreulich and PyleValidation studyVertebral fractures

Identifiers

PMID41120763

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.