Evidence map›Paper›PMID 41120720›Full record

ArticleCommunications biology2025

AAV9-mediated KCC2 upregulation enhances functional recovery following cervical spinal cord injury.

Mohammad-Masoud Zavvarian, Akshat D Modi, Mohamad Khazaei, Zixiang Luo, Alexander R Velumian, Omar Imad Hassan, James Hong, Christopher S Ahuja, Zeenal H Patel, Miao He and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mohammad-Masoud ZavvarianDivision of Genetics and Development, Krembil Brain Institute, University Health Network, Toronto, ON, Canada.
Akshat D ModiDivision of Genetics and Development, Krembil Brain Institute, University Health Network, Toronto, ON, Canada.ORCID http://orcid.org/0000-0003-1086-3670
Mohamad KhazaeiDivision of Genetics and Development, Krembil Brain Institute, University Health Network, Toronto, ON, Canada.
Zixiang LuoDivision of Genetics and Development, Krembil Brain Institute, University Health Network, Toronto, ON, Canada.
Alexander R VelumianDivision of Genetics and Development, Krembil Brain Institute, University Health Network, Toronto, ON, Canada.
Omar Imad HassanDivision of Genetics and Development, Krembil Brain Institute, University Health Network, Toronto, ON, Canada.
James HongDivision of Genetics and Development, Krembil Brain Institute, University Health Network, Toronto, ON, Canada.
Christopher S AhujaDivision of Genetics and Development, Krembil Brain Institute, University Health Network, Toronto, ON, Canada.
Zeenal H PatelDivision of Genetics and Development, Krembil Brain Institute, University Health Network, Toronto, ON, Canada.
Miao HeF.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.
Zhigang HeF.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0001-6080-6880
Michael G FehlingsDivision of Genetics and Development, Krembil Brain Institute, University Health Network, Toronto, ON, Canada. michael.fehlings@uhn.ca.ORCID http://orcid.org/0000-0002-5722-6364

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Following traumatic cervical spinal cord injury (SCI), injury-induced functional changes within the perilesional forelimb circuits are an important cause of neurological dysfunction. K

Indexed as

Cervical CordDependovirusGenetic TherapyRecovery of FunctionSpinal Cord InjuriesSymportersAnimalsDisease Models, AnimalFemaleGenetic VectorsK Cl- CotransportersRatsRats, Sprague-DawleyUp-RegulationK Cl- CotransportersSymporters

Identifiers

PMID41120720
PMCPMC12540893

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.