ArticleNature metabolism2025
Microbial metabolite indole-3-propionic acid drives mitochondrial respiration in CD4
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Article in Nature metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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31citing papers in PubMed, 2 pooled it
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Mechanistic pathways linking gut microbial metabolites, microbial structural products, and host-microbe co-metabolites to mitochondrial function.Gut microbes · 2026Pooled it
- Large-scale multi-trait genome-wide analysis for inflammatory bowel disease reveals new insights into its molecular mechanisms and emphasizes the roles of systemic immune regulation.Briefings in bioinformatics · 2025Pooled it
- Gut microbiota and immunometabolism in obesity.Gut microbes · 2026Review
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- Gut microbiome and pregnancy complications: emerging evidence and mechanistic insights.Gut microbes · 2026Review
- Dietary and nutritional strategies for reducing disease risk associated with antibiotic-induced dysbiosis.Gut microbes · 2026Review
- Towards optimizing the host response to biotics: a report of an International Scientific Association for Probiotics and Prebiotics working group.Gut microbes · 2026Article
- Microbiota-Associated Amino Acid Metabolites in Inflammatory Bowel Disease: Emerging Key Players in the Host-Microbe Interface.Microorganisms · 2026Review
- Limosilactobacillus reuteri orchestrates IAA-mediated mitochondrial homeostasis and stem cell renewal against intestinal oxidative injury in aged hens.Journal of animal science and biotechnology · 2026Article
- A dual-targeted mitochondria and lipid droplets near-infrared probe for visualizing viscosity and sulfur dioxide fluctuations during inflammatory microenvironment.Mikrochimica acta · 2026Article
- Tobacco smoking disrupts bile acid and tryptophan metabolism in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2026Article
- Prevention of Intestinal Inflammation and Gut Dysbiosis by Prebiotic Grape Seed Flour in Mice with DSS-Induced Colitis.Pharmaceuticals (Basel, Switzerland) · 2026Article
- The Gut-Pancreas Axis in Type 1 Diabetes: Emerging Insights into Microbiota and Immune Interactions.International journal of molecular sciences · 2026Review
- Cell Signaling by Tryptophan Catabolism.Biochemistry · 2026Review
- Living Hydrogels: Harnessing Microorganism-Material Synergy for Next-Generation Therapeutics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Review
- TibetanNutrients · 2026Article
- L-kynurenine reshapes immune microenvironment to alleviate methamphetamine-induced chronic lung injury through gut-lung axis.Microbiome · 2026Article
- Probiotics as Microbiome Modulators in Male Infertility: Rethinking Dysbiosis Across the Gut-Testis Axis.Journal of personalized medicine · 2026Review
- Classification of intestinal inflammation driven by gut microbiota metabolites: a new paradigm for precision treatment of cardiovascular diseases.Frontiers in microbiology · 2026Review
Corrections and comments
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Authors and funding
31 authors.
Qing LiSorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, Paris, France.
Rodrigo de Oliveira FormigaSorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, Paris, France.
Virginie PuchoisSorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, Paris, France.
Laura CreusotSorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, Paris, France.
Ahmad Haidar AhmadSorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, Paris, France.
Salomé AmouyalSorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, Paris, France.
Márcio Augusto Campos-RibeiroInstitut Pasteur, Mitochondrial Biology Unit, CNRS UMR 3691, Université Paris Cité, Paris, France.ORCID http://orcid.org/0000-0002-8431-4968
Yining ZhaoInstitut Pasteur, Mitochondrial Biology Unit, CNRS UMR 3691, Université Paris Cité, Paris, France.
Danielle M M HarrisInstitute of Clinical Molecular Biology, Kiel University and University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany.ORCID http://orcid.org/0000-0002-1950-399X
Frederic LasserreToxalim (Research Centre in Food Toxicology), INRAE, ENVT, INP-Purpan, UPS, Université de Toulouse, Toulouse, France.
Sandrine Ellero-SimatosToxalim (Research Centre in Food Toxicology), INRAE, ENVT, INP-Purpan, UPS, Université de Toulouse, Toulouse, France.ORCID http://orcid.org/0000-0002-9282-1804
Hervé GuillouToxalim (Research Centre in Food Toxicology), INRAE, ENVT, INP-Purpan, UPS, Université de Toulouse, Toulouse, France.
Zhan HuangSorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, Paris, France.
Loic BrotSorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, Paris, France.
Yuhang HuSorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, Paris, France.
Loic CholletGut, Liver & Microbiome Research (GLIMMER) FHU, Paris, France.ORCID http://orcid.org/0009-0005-0165-625X
Camille DanneSorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, Paris, France.ORCID http://orcid.org/0000-0003-0971-8310
Cyril ScandolaInstitut Pasteur, Université Paris Cité, Ultrastructural Bioimaging Unit, Paris, France.ORCID http://orcid.org/0000-0002-5305-9095
Tatiana LedentSorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, Paris, France.
Guillaume ChevreuxUniversité Paris Cité, CNRS, Institut Jacques Monod, Paris, France.
Rafael J ArgüelloAix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France.ORCID http://orcid.org/0000-0001-9785-3883
Marcelo De Carvalho BittencourtUniversité de Lorraine, CNRS, IMoPA, Nancy, France.
Jessica BettingerUniversité de Lorraine, CNRS, IMoPA, Nancy, France.ORCID http://orcid.org/0009-0003-1129-2408
Maud D'Aveni-PineyUniversité de Lorraine, CNRS, IMoPA, Nancy, France.
David MoulinUniversité de Lorraine, CNRS, IMoPA, Nancy, France.ORCID http://orcid.org/0000-0001-6619-5769
Stefan SchreiberInstitute of Clinical Molecular Biology, Kiel University and University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany.ORCID http://orcid.org/0000-0003-2254-7771
Konrad AdenInstitute of Clinical Molecular Biology, Kiel University and University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany.ORCID http://orcid.org/0000-0003-3482-7316
Nathalie RolhionSorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, Paris, France.
Marie-Laure MichelGut, Liver & Microbiome Research (GLIMMER) FHU, Paris, France.
Timothy WaiInstitut Pasteur, Mitochondrial Biology Unit, CNRS UMR 3691, Université Paris Cité, Paris, France.ORCID http://orcid.org/0000-0002-6770-6222
Harry SokolSorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, Paris, France. harry.sokol@gmail.com.ORCID http://orcid.org/0000-0002-2914-1822
Funding
Bundesministerium für Bildung und Forschung (Federal Ministry of Education and Research) "Try-IBD" 01ZX1915AEC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) ERC-2021-COG-101043802
Abstract
The gut microbiota and its metabolites critically regulate immune cell phenotype, function and energy metabolism. We screened a collection of gut microbiota-related metabolites to identify modulators of mitochondrial metabolism in T cells. Here we show that indole-3-propionic acid (IPA) stimulates mitochondrial respiration of CD4
Indexed as
CD4-Positive T-LymphocytesGastrointestinal MicrobiomeIndolesInflammationMitochondriaPropionatesAnimalsCell RespirationColitisFatty AcidsMiceMice, Inbred C57BLOxidation-ReductionFatty Acidsindolepropionic acidIndolesPropionates
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