ArticleScientific reports2025
Nanoindentation under retrocorneal pressure to determine the biomechanical response of the human cornea to accelerated UVA crosslinking and riboflavin osmolarity ex vivo.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Riboflavin-mediated UVA corneal crosslinking (CXL) is an established treatment to halt the progression of keratoconus. However, the biomechanical effects of accelerated protocols and varying riboflavin osmolarities under physiological conditions remain poorly understood. Traditional biomechanical assessments using nanoindentation typically analyze tissue flatmounts, disregarding the natural tissue strain exerted by intraocular pressure. We developed a novel experimental setup combining nanoindentation with adjustable retrocorneal fluid pressure (RCP) to simulate physiological conditions during measurements. Using this approach, we first examined five corneas under incrementally increasing RCP levels to quantify the effect of tissue pre-tension on biomechanical properties. In a subsequent series, we investigated 70 human corneas to evaluate seven different protocols, including accelerated treatment protocols and different riboflavin osmolarities, by analyzing the Hertz-elastic modulus (E
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