Evidence map›Paper›PMID 41120678›Full record

ArticleEMBO molecular medicine2025

ER stress induced mitochondrial dysfunction drives Treg instability in coronary artery disease.

Smriti Parashar, Mohammad Oliaeimotlagh, Payel Roy, Qingkang Lyu, Anusha Bellapu, Mikhail Fomin, Sunil Kumar, Yan Wang, Chantel C McSkimming, Coleen A McNamara and 1 more

Abstract read
In one paragraph

Article in EMBO molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Nanomaterials-Based Immunotherapy for Atherosclerosis.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  4. Checkpoint inhibitors create rogue regulatory T cells.The Journal of clinical investigation · 2026
    Article
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Smriti ParasharImmunology Center of Georgia, Augusta University, Augusta, GA, USA. sparashar@augusta.edu.ORCID http://orcid.org/0000-0002-6348-2612
Mohammad Oliaeimotlagh *Immunology Center of Georgia, Augusta University, Augusta, GA, USA.
Payel Roy *Immunology Center of Georgia, Augusta University, Augusta, GA, USA.
Qingkang LyuImmunology Center of Georgia, Augusta University, Augusta, GA, USA.
Anusha BellapuImmunology Center of Georgia, Augusta University, Augusta, GA, USA.
Mikhail FominImmunology Center of Georgia, Augusta University, Augusta, GA, USA.
Sunil KumarImmunology Center of Georgia, Augusta University, Augusta, GA, USA.
Yan WangImmunology Center of Georgia, Augusta University, Augusta, GA, USA.
Chantel C McSkimmingCarter Immunology Center, University of Virginia, Charlottesville, VA, USA.
Coleen A McNamaraCarter Immunology Center, University of Virginia, Charlottesville, VA, USA.
Klaus LeyImmunology Center of Georgia, Augusta University, Augusta, GA, USA. kley@augusta.edu.ORCID http://orcid.org/0000-0001-9339-3672

Funding

Project 4: APOB-specific CD4 and CD8 T cells exacerbate atherosclerosisP01HL136275 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Catherine C Hedrick · 2017 to 2026
$25.5M
Vascular macrophages and T cells in atherosclerosisR35HL145241 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI LEY, KLAUS F. · 2019 to 2025
$5.9M
NHLBI NIH HHS P01 HL136275NHLBI NIH HHS R35 HL145241
6 · The paper itself

Abstract

Under conditions of chronic unresolved inflammation characteristic of atherosclerosis, regulatory CD4

Indexed as

Coronary Artery DiseaseEndoplasmic Reticulum StressMitochondriaT-Lymphocytes, RegulatoryApoptosisHumansMaleAtherosclerosisER StressexTregsMitochondrial DysfunctionTregs

Identifiers

PMID41120678
PMCPMC12686412

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.