Evidence map›Paper›PMID 41120637›Full record

ArticleScientific reports2025

MAPK14 and its associated lncRNAs are up-regulated in lung tumors.

Shahab Shahgaldi, Bashdar Mahmud Hussen, Solat Eslami, Arda Kiani, Soudeh Ghafouri-Fard

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PubMed Full text at PMC Publisher
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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Shahab ShahgaldiDepartment of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Bashdar Mahmud HussenDepartment of Clinical Analysis, College of Pharmacy, Hawler Medical University, Kurdistan Region, Erbil, Iraq.
Solat EslamiDepartment of Medical Biotechnology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
Arda KianiTracheal Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Soudeh Ghafouri-FardDepartment of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran. s.ghafourifard@sbmu.ac.ir.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MAPK14 and its related lncRNAs have been found to take part in the pathogenesis of cancers. We analyzed expression of MAPK14 and three related lncRNAs, namely NORAD, HCG11 and POLR1HASP (ZNRD1ASP) in 42 pairs of lung tumors and their nearby normal samples. ZNRD1ASP was the mostly up-regulated gene in the tumors in the current study with the expression ratio (95% CI) of 10.46 (3.1-35.4). NORAD, HCG11 and MAPK14 were the other up-regulated genes in order with expression ratios (95% CIs) of 9.57 (2.99-30.6), 5.11 (1.65-15.8) and 4.9 (1.92-12.6), respectively. ROC curve analyses revealed that ZNRD1ASP had the highest accuracy and AUC values among the studied genes. However, NORAD with the sensitivity of 0.78 and negative predictive value of 70% performed better than the other transcripts in these two parameters. Taken together, MAPK14 and its related lncRNAs may have important roles in the pathogenesis of lung cancer.

Indexed as

Gene Expression Regulation, NeoplasticLung NeoplasmsRNA, Long NoncodingUp-RegulationBiomarkers, TumorFemaleHumansMaleROC CurveBiomarkers, TumorRNA, Long NoncodinglncRNALung cancerMAPK14

Identifiers

PMID41120637
PMCPMC12540707

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