Evidence map›Paper›PMID 41120571›Full record

ArticleNature biomedical engineering2026

Targeting circulating mechanoresponsive monocytes and macrophages to reduce fibrosis.

Kellen Chen, Michelle Griffin, Dominic Henn, Katharina S Berryman, Dharshan Sivaraj, Hudson C Kussie, Clark A Bonham, Eamonn McKenna, Maria Gracia Mora Pinos, Abdelrahman M Alsharif and 24 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. A practical toolbox for modelling fibrosis in vitro.Nature biomedical engineering · 2026
    Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Kellen Chen *Department of Surgery, University of Arizona College of Medicine, Tucson, AZ, USA. kellenchen@arizona.edu.ORCID http://orcid.org/0000-0002-7023-7850
Michelle Griffin *Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Dominic HennDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Katharina S BerrymanDepartment of Surgery, University of Arizona College of Medicine, Tucson, AZ, USA.
Dharshan SivarajDepartment of Surgery, University of Arizona College of Medicine, Tucson, AZ, USA.ORCID http://orcid.org/0000-0001-7453-0045
Hudson C KussieDepartment of Surgery, University of Arizona College of Medicine, Tucson, AZ, USA.ORCID http://orcid.org/0000-0001-9877-2313
Clark A BonhamDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Eamonn McKennaDepartment of Surgery, University of Arizona College of Medicine, Tucson, AZ, USA.ORCID http://orcid.org/0000-0002-2324-592X
Maria Gracia Mora PinosDepartment of Surgery, University of Arizona College of Medicine, Tucson, AZ, USA.
Abdelrahman M AlsharifDepartment of Surgery, University of Arizona College of Medicine, Tucson, AZ, USA.ORCID http://orcid.org/0009-0002-7965-1203
Fidel SaenzDepartment of Surgery, University of Arizona College of Medicine, Tucson, AZ, USA.
Nicholas E MatthewsDepartment of Surgery, University of Arizona College of Medicine, Tucson, AZ, USA.ORCID http://orcid.org/0009-0007-1609-7774
Maisam JafriDepartment of Surgery, University of Arizona College of Medicine, Tucson, AZ, USA.
Jonathan P YasmehDepartment of Surgery, University of Arizona College of Medicine, Tucson, AZ, USA.
Mimi R BorrelliDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Savana HuskinsDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Sydney SteeleDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Amelia B KnochelDepartment of Surgery, University of Arizona College of Medicine, Tucson, AZ, USA.
Mansi SinghDepartment of Surgery, University of Arizona College of Medicine, Tucson, AZ, USA.ORCID http://orcid.org/0009-0004-7045-1410
Andrew C HostlerDepartment of Surgery, University of Arizona College of Medicine, Tucson, AZ, USA.
Melissa LeeolouDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-9223-2380
William W HahnDepartment of Surgery, University of Arizona College of Medicine, Tucson, AZ, USA.
David PerraultDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-3664-6930
Darren AbbasDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-5218-1665
Nicholas GuardinoDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-8577-8038
Benjamin ThomasDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Janos A BarreraDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-6811-8337
Chikage NoishikiDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Artem A TrotsyukDepartment of Surgery, University of Arizona College of Medicine, Tucson, AZ, USA.ORCID http://orcid.org/0000-0001-8886-5583
Jagannath PadmanabhanDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-1096-6637
Michael JanuszykDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Mohammad KhreissDepartment of Surgery, University of Arizona College of Medicine, Tucson, AZ, USA.
Michael T LongakerDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-1430-8914
Geoffrey C GurtnerDepartment of Surgery, University of Arizona College of Medicine, Tucson, AZ, USA. gurtner@surgery.arizona.edu.ORCID http://orcid.org/0009-0002-0706-8035

Funding

Center for Dental, Oral, and Craniofacial Tissue and Organ Regeneration (C-DOCTOR)U24DE026914 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAI, YANG, CHEN, YONG · 2017 to 2019
$12.0M
Reversal of Progenitor Cell Deficits in DiabetesR01DK074095 · NIDDK · UNIVERSITY OF ARIZONA · PI GURTNER, GEOFFREY C · 2005 to 2025
$6.4M
SHORT-TERM TRAINING STUDENTS IN HEALTH PROFESSIONAL SCHOT35HL007479 · NHLBI · UNIVERSITY OF ARIZONA · PI GEOFFREY C GURTNER, JAMES Kuang-Jan LIAO · 1985 to 2026
$4.4M
National Science Foundation (NSF) ECCS-1542152NHLBI NIH HHS T35 HL007479NIDCR NIH HHS U24 DE026914NIDDK NIH HHS R01 DK074095Plastic Surgery Foundation (PSF) 837107United States Department of Defense | United States Army | Army Medical Command | Armed Forces Institute of Regenerative Medicine (AFIRM) W81XWH-13-2-0054U.S. Department of Health & Human Services | National Institutes of Health (NIH) 1S10OD021763
6 · The paper itself

Abstract

In response to injury, a variety of different cells are recruited to sites of injury to facilitate healing. Recent studies have examined the importance of the heterogeneity of tissue resident fibroblasts and mechanical signalling pathways in healing and fibrosis. However, tissue repair and the inflammatory response also involves blood cells that are recruited from the circulation. Here we identify mechanoresponsive myeloid subpopulations present in scar and unwounded skin. We then modulate these subpopulations by manipulating mechanical strain in vivo and in vitro and find that specifically targeting myeloid mechanical signalling is sufficient to reduce the pro-fibrotic myeloid subpopulations and restore the native, anti-inflammatory subpopulations. In addition, myeloid-specific mechanotransduction ablation also downregulates downstream pro-fibrotic fibroblast transcriptional profiles, reducing scar formation. As inflammatory cells circulate and home to injury sites during the initial healing phases in all organs, focusing on mechanoresponsive myeloid subpopulations may generate additional directions for systemic immunomodulatory therapies to target fibrosis and other diseases across other internal organ systems.

Indexed as

FibrosisMacrophagesMechanotransduction, CellularMonocytesAnimalsCicatrixFibroblastsHumansInflammationMiceSkinWound Healing

Identifiers

PMID41120571
PMCPMC13279266

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.