Evidence map›Paper›PMID 41120566›Full record

ArticleScientific reports2025

Phytosphingosine, a sphingolipid isolated from fungal endophyte Penicillium oxalicum, exerts cytotoxic effects against breast cancer cells and shows blood compatibility.

Ashish Verma, Swati Singh, Priyamvada Gupta, Harshita Tiwari, Lalit Kumar, M K Bharty, Vibhav Gautam

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ashish VermaCentre of Experimental Medicine and Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India.
Swati Singh *Centre of Experimental Medicine and Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India.
Priyamvada Gupta *Centre of Experimental Medicine and Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India.
Harshita TiwariCentre of Experimental Medicine and Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India.
Lalit KumarDepartment of Urology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India.
M K BhartyDepartment of Chemistry, Institute of Science, Banaras Hindu University, Varanasi, 221005, India.
Vibhav GautamCentre of Experimental Medicine and Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India. vibhav.gautam4@bhu.ac.in.

Funding

Banaras Hindu University Institution of Eminence (IoE) Seed GrantCouncil of Science and Technology, U.P. CST/D-1187
6 · The paper itself

Abstract

Plant-associated fungal endophytes hold great potential to synthesize metabolites similar to their host, with potential anticancer effects. The present study aims to identify lead compound in the ethyl acetate (EA) extract of fungal endophyte, Penicillium oxalicum, associated with a medicinal plant Amoora rohituka, responsible for the anti-breast cancer activity. The crude extract of P. oxalicum was subjected to High-performance liquid chromatography (HPLC) analysis and further, bioactivity-guided fractionation was performed for HPLC fractions based on cell viability assay. The potential fraction further showed dose-dependent generation of nitric oxide in breast cancer cells that indicates their activity in the induction of oxidative stress. The characterization of potential fraction was done using different analytical techniques, such as liquid chromatography coupled with quadrupole time of flight mass spectrometry (LC-Q-TOF-MS), high-resolution mass spectrometry (HRMS), Fourier transform-infrared (FTIR) spectroscopy, and both

Indexed as

Antineoplastic AgentsBreast NeoplasmsEndophytesPenicilliumSphingolipidsSphingosineCell Line, TumorCell SurvivalChromatography, High Pressure LiquidFemaleHumansMCF-7 CellsNitric OxideAntineoplastic AgentsNitric OxidephytosphingosineSphingolipidsSphingosineAmoora rohitukaBreast cancerFungal endophyteHemolysisPenicillium oxalicumPhytosphingosine

Identifiers

PMID41120566
PMCPMC12540787

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.