Evidence map›Paper›PMID 41120542›Full record

ArticleScientific reports2025

Implantation of a vascular access button in mice.

Suguru Yamauchi, Kaitlyn Ecoff, Andrei Gurau, Kristen P Rodgers, Yuping Mei, Franck Housseau, Yun Chen, John Michel, Omkar Dhaygude, Sakura Minamisawa and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Suguru YamauchiDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kaitlyn EcoffDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Andrei GurauDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kristen P RodgersDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Yuping MeiDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Franck HousseauDepartment of Oncology and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Yun ChenDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, USA.
John MichelDepartment of Oncology and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Omkar DhaygudeDepartment of Oncology and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sakura MinamisawaDepartment of Oncology and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Ziying XuDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Feiyu ChenDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Frank BosmansMolecular Physiology and Neurophysics Group, Department of Basic and Applied Medical Sciences, Faculty of Medicine and Public Health, University of Ghent, Ghent, Belgium.
Andreas S BarthDepartment of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jinny S HaDivision of Thoracic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Takumi IwasawaInstitute of Life Innovation Studies, Toyo University, Tokyo, Japan.
Kazunori KatoInstitute of Life Innovation Studies, Toyo University, Tokyo, Japan.
Miki YamauchiInternational Collaborative Research Administration, Juntendo University School of Medicine, Tokyo, Japan.
Hajime OritaDepartment of Esophageal and Gastroenterological Surgery, Faculty of Medicine, Juntendo University, Tokyo, Japan.
Shinji MineDepartment of Esophageal and Gastroenterological Surgery, Faculty of Medicine, Juntendo University, Tokyo, Japan.
Tetsu FukunagaDepartment of Esophageal and Gastroenterological Surgery, Faculty of Medicine, Juntendo University, Tokyo, Japan.
Malcolm V BrockDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA. mabrock@jhmi.edu.

Funding

Medical Scientist Training ProgramT32GM136577 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ANDREA L COX · 2020 to 2026
$13.4M
Clinical and Laboratory Research Training for Surgical OncologistsT32CA126607 · NCI · JOHNS HOPKINS UNIVERSITY · PI CAMERON, ANDREW M. · 2008 to 2024
$6.0M
Sodium channel mutations as a possible cause for primary dysautonomiaR01NS126398 · NINDS · JOHNS HOPKINS UNIVERSITY · PI MALCOLM V BROCK · 2023 to 2026
$1.9M
Dysautonomia International 90097658NCI NIH HHS T32 CA126607NIGMS NIH HHS T32 GM136577NIH HHS R01NS126398NIH HHS T32CA126607NIH Medical Scientist Training Program T32GM136577NINDS NIH HHS R01 NS126398
6 · The paper itself

Abstract

Vascular access presents unique challenges in experimental mice due to their small size and anatomical constraints. Achieving reliable vascular access is crucial for optimizing experimental outcomes, especially in protocols requiring serial blood sampling or repeated intravascular therapy. Although vascular access buttons (VABs) offer significant advantages, their widespread adoption has been limited by technical challenges and a lack of comprehensive validation regarding their safety, feasibility, and long-term management. To address these gaps, we conducted a comprehensive evaluation of VAB implantation in mice. The technical success rate was 90.2%, and the 28-day survival rate was 80.4%. Optimal catheter insertion lengths determined by intraoperative and autopsy findings, and computed tomography were 9.5 ± 0.6 mm (20-25 g), 10.1 ± 0.8 mm (25-30 g), and 11.2 ± 0.5 mm (> 30 g), respectively. Catheter patency was analyzed by stratifying the cohort into groups based on physical parameters such as catheter tip geometry, heparin concentration in the maintenance solution, and frequency of catheter maintenance procedures. Although approximately half of the mice lost complete catheter patency by day 14, the majority maintained partial patency at day 28 in all experimental groups except for two cases of complete occlusion in the 2 Fr square tip, low-dose heparin, weekly maintenance group. The evaluation of biodistribution and clearance with indocyanine green indicated that VAB administration may have advantages over conventional venipuncture. These standardized methodologies can provide a framework for diverse biomedical research applications, enhancing both the efficiency and reproducibility of studies requiring reliable vascular access.

Indexed as

Catheters, IndwellingVascular Access DevicesAnimalsFemaleMaleMiceExternal jugular veinVascular accessVascular access buttonVascular catheter

Identifiers

PMID41120542
PMCPMC12541028

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.