Evidence map›Paper›PMID 41120501›Full record

ArticleScientific reports2025

Secret elixirs of nature: extract type shapes the phytochemical-mediated synthesis and anticancer potential of ZnO and Fe

Rana Ahmed El-Fitiany, Ahlam Barhumi, Aisha Aldhaheri, Raya Almazrouei, Shaikha Alameri, Shama Albloushi, Afra AlBlooshi, Mohammad Ahmad Khasawneh

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Integrated UHPLC-QTOF-MSJournal of computer-aided molecular design · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rana Ahmed El-FitianyDepartment of Chemistry, College of Science, United Arab Emirates University, Sheikh Khalifa Bin Zayed St, Asharij, Al-Ain, Abu Dhabi, United Arab Emirates.ORCID http://orcid.org/0000-0002-4477-1873
Ahlam BarhumiDepartment of Chemistry, College of Science, United Arab Emirates University, Sheikh Khalifa Bin Zayed St, Asharij, Al-Ain, Abu Dhabi, United Arab Emirates.
Aisha AldhaheriDepartment of Chemistry, College of Science, United Arab Emirates University, Sheikh Khalifa Bin Zayed St, Asharij, Al-Ain, Abu Dhabi, United Arab Emirates.
Raya AlmazroueiDepartment of Chemistry, College of Science, United Arab Emirates University, Sheikh Khalifa Bin Zayed St, Asharij, Al-Ain, Abu Dhabi, United Arab Emirates.
Shaikha AlameriDepartment of Chemistry, College of Science, United Arab Emirates University, Sheikh Khalifa Bin Zayed St, Asharij, Al-Ain, Abu Dhabi, United Arab Emirates.
Shama AlbloushiDepartment of Chemistry, College of Science, United Arab Emirates University, Sheikh Khalifa Bin Zayed St, Asharij, Al-Ain, Abu Dhabi, United Arab Emirates.
Afra AlBlooshiDepartment of Chemistry, College of Science, United Arab Emirates University, Sheikh Khalifa Bin Zayed St, Asharij, Al-Ain, Abu Dhabi, United Arab Emirates.ORCID http://orcid.org/0000-0002-8565-0111
Mohammad Ahmad KhasawnehDepartment of Chemistry, College of Science, United Arab Emirates University, Sheikh Khalifa Bin Zayed St, Asharij, Al-Ain, Abu Dhabi, United Arab Emirates. mohammad.khasawneh@uaeu.ac.ae.ORCID http://orcid.org/0000-0001-5853-8311

Funding

United Arab Emirates University 131031/ PhD-62
6 · The paper itself

Abstract

Recently, the field of phyto-nanomedicines has emerged as a promising avenue of research for generating sustainable, economically viable, and medically safe plant-based metal nanoparticles (NPs) with boosted therapeutic potential. Despite advancements, the literature remains inconclusive regarding the optimal extraction protocol for these plants to yield NPs with maximized functionality. Therefore, this study pioneered the use of two diverse UAE-Salvadora persica extracts; namely, aqueous and hydro-alcoholic, in the biological synthesis of green zinc and iron oxides NPs, aiming to resolve the research gap concerning the ideal extraction protocol for biomedical green NPs' production. Our findings revealed that the alcoholic extract yielded NPs with superior phytochemical surface coating, and higher phenolic (42.94 ± 2.79 µg of GAE/mg of DW) and flavonoid (45.63 ± 1.88 µg of QU/mg of DW) contents, resulting in stronger antioxidant properties with IC

Indexed as

Antineoplastic AgentsFerric CompoundsMetal NanoparticlesPhytochemicalsPlant ExtractsZinc OxideAntioxidantsCell Line, TumorGreen Chemistry TechnologyHumansAntineoplastic AgentsAntioxidantsFerric Compoundsferric oxidePhytochemicalsPlant ExtractsZinc OxideAntioxidantLC/MS/MSNanoparticlesPhytochemical profilingSalvadora persicaSkin cancer

Identifiers

PMID41120501
PMCPMC12540883

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.